نتایج جستجو برای: normal data conversion cox

تعداد نتایج: 2984912  

Journal: :American journal of physiology. Renal physiology 2003
Hayo Castrop Jurgen Klar Charlotte Wagner Klaus Hocherl Armin Kurtz

Because across-the-board data indicate that renin and cyclooxygenase-2 (COX-2) expression in the kidney cortex are regulated in parallel and because ANG II can inhibit COX-2 expression, the purpose of our study was to characterize a potential general inhibitory feedback of the renin-angiotensin system on renocortical COX-2 expression in vivo. Rats were fed a high-, normal-, or low-salt diet or ...

Journal: :Acta Histochemica et Cytochemica 2008
Yuanxu Xu Li Yang Tian Yang Mingming Xiang Enyi Huang Xiaohua Lian

As an important member of the cyclooxygenase isoenzymes, cyclooxygenase-2 (COX-2) mainly catalyzes the first two steps in prostanoid synthesis. In mammalian animals, although COX-2 was thought to be rarely expressed in most normal tissues and was usually upregulated in a variety of epithelial tumors and inflammatory reactions, recently it was reported that COX-2 could localize in the epidermis ...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Matteo Fornai Corrado Blandizzi Luca Antonioli Rocchina Colucci Nunzia Bernardini Cristina Segnani Fabrizio De Ponti Mario Del Tacca

This study examines the role played by cyclooxygenase (COX) isoforms (COX-1 and -2) in the regulation of colonic neuromuscular function in normal rats and after induction of colitis by 2,4-dinitrobenzenesulfonic acid (DNBS). The expression of COX-1 and COX-2 in the colonic neuromuscular layer was assessed by reverse transcription-polymerase chain reaction and immunohistochemistry. The effects o...

A new group of 4-(Imidazolylmethyl) quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors and in-vitro anti breast cancer agents. In-vitro COX-1 and COX-2 inhibition studies showed that all the compounds were potent and selective inhibitors of the COX-2 isozyme with IC50 value...

Journal: :international journal of advanced biological and biomedical research 2013
amir hossein hashemian behrouz beiranvand mansour rezaei abdolrasoul bardideh eghbal zand-karimi

cox regression model serves as a statistical method for analyzing the survival data, which requires some options such as hazard proportionality. in recent decades, artificial neural network model has been increasingly applied to predict survival data. this research was conducted to compare cox regression and artificial neural network models in prediction of kidney transplant survival. the prese...

باغستانی, احمد رضا, حاجی زاده, ابراهیم, نور کجوری, هدی, پورحسینقلی, محمد‌امین ,

Background & Objectives: Cox regression model is one of the statistical methods in survival analysis. The use of smoothing techniques in Cox model makes the more accurate estimates for the parameters. Fractional polynomial is one of these techniques in Cox model. The aim of this study was to assess the effects of prognostic factors on survival of patients with gastric cancer using the fractiona...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Paola Nieri Cinzia Martinelli Corrado Blandizzi Nunzia Bernardini Rosamiria Greco Chiara Ippolito Mario Del Tacca Maria Cristina Breschi

The effects of selective cyclooxygenase (COX) isoform (COX-1, COX-2) inhibition, alone or in combination with nitric-oxide synthase (NOS) blockade, on in vitro tracheal muscle responsiveness to histamine were investigated in healthy and ovalbumin (OVA)-sensitized guinea pigs. Immunohistochemistry showed that COX-1 and COX-2 are constitutively present in normal guinea pig trachea, particularly i...

ربیعی, نیلوفر, روضاتی, محسن, غلامی فشارکی, محمد,

Background and Objectives: The Cox model is one of the methods used in survival data; however, the use of hierarchical data, such as the data of this study, violates the assumption of independence, the the Cox model cannot be used  assuming independence of observations. One of the important methods for analyzing survival hierarchy data is the use of the multilevel Cox model. In this method, in ...

Abdolrasoul Bardideh Amir Hossein Hashemian Behrouz Beiranvand, Eghbal Zand-Karimi Mansour Rezaei

Cox regression model serves as a statistical method for analyzing the survival data, which requires some options such as hazard proportionality. In recent decades, artificial neural network model has been increasingly applied to predict survival data. This research was conducted to compare Cox regression and artificial neural network models in prediction of kidney transplant survival. The prese...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Patrick A Adegboyega Omiyosoye Ololade Jamal Saada Randy Mifflin John F Di Mari Don W Powell

PURPOSE Recent data support the hypothesis that the inducible isoform of cyclooxygenase (COX-2) plays a role in the early stages of colonic carcinogenesis and that nonsteroidal anti-inflammatory drugs (NSAIDs) retard the development of colon cancer by modulating COX-2. However, the cell types responsible for producing COX-2 in colorectal adenomas remain a subject of controversy. EXPERIMENTAL ...

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