Introduction T1 mapping is a novel quantitative method for myocardial tissue characterization. Reference values of myocardium and blood have been established at 1.5T (Messroghli, MRM, 2007). CMR at 3T is a rapidly maturing field, and T1 values generally increase with magnetic field strength, making it necessary to establish new reference values at this higher field strength. The aim of this stu...

BACKGROUND Pain referral patterns of asymptomatic costotransverse joints have not been established. The objective of this study was to determine the pain referral patterns of asymptomatic costotransverse joints via provocative intra-articular injection. METHODS Eight asymptomatic male volunteers received a combined total of 21 intra-articular costotransverse joint injections. Fluoroscopic ima...

Ketoconazole is an orally effective, broad-spectrum, systemic antifungal agent. The pharmacokinetics and bioavailability of ketoconazole given as a 200-mg single dose in a tablet, suspension, or solution were studied in 24 fasting healthy males by using a crossover design. Levels of ketoconazole in plasma were determined for up to 48 h by a sensitive reverse-phase high-performance liquid chroma...

AIMS Obesity can modify the pharmacokinetics of lipophilic drugs. As beta-adrenoceptor blockers (BB) are often prescribed for obese patients suffering from hypertension or coronary heart disease, this study compares the pharmacokinetics of lipophilic beta-adrenoceptor blockers in obese and control subjects. METHODS Nine obese (157 +/- 24% of ideal body weight (IBW) mean +/- s.d.) and nine non...

AIMS To study the oesophageal pressures in normal Pakistani subjects using oesophageal manometry and compare the results from the studies done abroad. SETTING Ziauddin Medical University Hospital, North Nazimabad Karachi. SUBJECTS Twenty-five healthy subjects were studied. RESULTS Of 25 subjects 19 were males and 6 females. Their ages ranged from 14 to 67 years with a mean age of 41+16 ye...

The absorption of orally administered nafcillin sodium monohydrate buffered with calcium carbonate was studied in 10 healthy human volunteers. Dosages of 500 mg and 1 g were studied in fasting and nonfasting states. There was considerable individual variation in the absorption of nafcillin, although measurable serum concentrations were obtained in all subjects. With few exceptions, peak serum c...

The clinical use of therapeutic hypothermia has been rapidly expanding due to evidence of neuroprotection. However, the effect of hypothermia on specific pathways of drug elimination in humans is relatively unknown. To gain insight into the potential effects of hypothermia on drug metabolism and disposition, we evaluated the pharmacokinetics of midazolam as a probe for CYP3A4/5 activity during ...

Timolol ophthalmic solutions 0.5 per cent, 1.0 per cent, and 1.5 per cent lowered intraocular pressures significantly in normal human volunteers. Maximum lowering of the intraocular pressures was reached at two hours with the 0.5 per cent solution of timolol and at one hour with the 1.0 per cent and 1.5 per cent timolol ophthalmic solutions. The effect lasted the full seven hours of observation...

mutation responsible for atrial fibrillation and short QT syndrome in utero. Cardiovasc Res 2005;68:433–40. 3. Schimpf R, Wolpert C, Gaita F, Giustetto C, Borggrefe M. Short QT syndrome. Cardiovasc Res 2005;67:357–66. 4. Levy S. Epidemiology and classification of atrial fibrillation. J Cardiovasc Electrophysiol 1998;9 Suppl 8:S78–82. 5. Jost N, Virag L, Bitay M, et al. Restricting excessive car...

Flatulence can cause discomfort and distress but there are few published data of normal patterns and volumes. Twenty four hour collections were made using a rectal catheter in 10 normal volunteers taking their normal diet plus 200 g baked beans. Total daily volume ranged from 476 to 1491 ml (median 705 ml). Women and men (both n = 5) expelled equivalent amounts. The median daily flatus hydrogen...