Sobre el coste-efectividad del dabigatrán To the Editor, The introduction of new oral anticoagulants for the prevention of thrombotic events in nonvalvular atrial fibrillation continues to be a subject of debate. One controversial issue is its cost. In a recent issue of the Revista Española de Cardiologı´a, Gonzá lez-Juanatey et al. 1 reported that dabigatran was cost-effective compared with vi...

BACKGROUND International normalized ratio (INR) self-testing can improve the management of anticoagulation therapy with warfarin for the patients following mechanical heart valve replacement. Several reviews and studies have demonstrated self-management as an option to improve patient's outcome considerably after mechanical heart valve replacement. We sought to analyze the security, economy and...

The life-cycle impacts of site characterization, an important component most geotechnical engineering projects, are typically not considered in practice nor have they been studied detail. A sustainability assessment (LCSA) was performed to evaluate the environmental and economic several common investigation methods. potential these methods were computed provide normalized metrics for mobilizati...

BACKGROUND Screening for hereditary hemochromatosis is traditionally done by using serum iron studies. However, mutation analysis of the hemochromatosis-associated HFE gene has recently become available. OBJECTIVE To compare the cost-effectiveness of no screening with four screening strategies that incorporate HFE gene testing or serum iron studies. DESIGN Cost-effectiveness analysis. DAT...

In order to deliver a complete reliable software product, testing is performed. As testing phase carries on, cost of testing process increases and it directly affects the overall project cost. Many a times it happens that the actual cost becomes more than the estimated cost. Cost is considered as the most important parameter with respect to software testing, in software industry. In recent year...

This study analyzes whether cardiorespiratory exercise performance is impaired in obese children when parameters of aerobic exercise function are used that are independent of body mass. Twenty-one obese patients (mean age 11.6 ± 2.5 years) were studied and compared with 22 normal controls of the same age range (11.4 ± 2.2 years; p = .78). All participants underwent square wave exercise testing ...

This paper presents a novel algorithm for sketch-based image retrieval. The approach enables measuring the similarity between a full color multi-component model image and a black and white sketched query and needs no cost intensive image segmentation. Two different procedures, based on strong edges of the model image and thinned outline of the sketched image, are exploited to derive two abstrac...

Within the software development departments of ASELSAN, software products are developed by using different software development models and test activities are carried out progressively within the process. Considering the continuous improvement of test design activities in a specified process, test effort estimation has a significant role during the project planning. In this article, the method ...