نتایج جستجو برای: novel anticancer agent
تعداد نتایج: 1047481 فیلتر نتایج به سال:
Selective green-light triggered release of an anticancer agent under physiological conditions from a supramolecular hydrogel.
Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, little is known about its anticancer mechanism. Here, we show that CPT inhibited cancer cell proliferation by arresting cells in G(1)-G(0) phase of the cell cycle. This is associated with the inhibition of cyclin D1 expression and retinoblastoma (Rb) protein ph...
There is an increasing interest in development of novel anticancer agents that target oncogenes. We have recently discovered that nuclear factor of activated T cells 1 (NFAT1) is a novel regulator of the Mouse Double Minute 2 (MDM2) oncogene and the NFAT1-MDM2 pathway has been implicated in human cancer development and progression, justifying that targeting the NFAT1-MDM2 pathway could be a nov...
We previously reported the potential of a novel small molecule (E)-methyl 3-(1-(4-methoxybenzyl)-2, 3-dioxoindolin-5-yl) acrylate (HKL 2-3-15) as an anticancer agent. This study was focused on the molecular mechanisms by which HKL 2-3-15 exerts its cytotoxic activity in human gastric cancer MGC-803 cells. We showed that HKL 2-3-15 induced G2/M phase arrest in a time-dependent and dose-dependent...
Many oncoproteins are considered undruggable because they lack enzymatic activities. In this study, we present a small-molecule-based anticancer agent that acts by inhibiting dimerization of the oncoprotein survivin, thereby promoting its degradation along with spontaneous apoptosis in cancer cells. Through a combination of computational analysis of the dimerization interface and in silico scre...
Hydroxamic acids serve as a monsulfhydril bisubstrate analog inhibition of fernesyl protein transferase (FPT), the enzyme catalysing fernesylation of p21ras. Tumor necrosis factor (TFN) is specifically prevented by synthetic hydroxamic acid-based metalloproteinase inhibitors. Suberoyanilide hydroxamic acid (SAHA) have been identified as histone deacetylase inhibitors based on their ability to i...
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