BACKGROUND In recent years reports from a number of countries, including Sweden, describe problems with diarrhoea in newborn piglets despite the use of previously effective preventive measures. This seemingly altered disease pattern of neonatal porcine diarrhoea (NPD) warrants investigations on the magnitude and manifestation of the problem. The aim of the present study was to investigate the h...

In last decades, New Product Development (NPD) process has become crucial for the company success. Many efforts have been paid in order to identify methods and tools able to improve NPD, but successful models are still missing or not easily followed. Companies find difficult to implement comprehensive models for improving their NPD process, and often they aren’t even aware on how they actually ...

Much discussion in the new product development (NPD) literature is concerned with describing blueprints for more effective systems for managing the process. Features of the emergent pattern of good practice in NPD include cross-functional team working, early involvement, effective project management arrangements and learning systems. However, there is relatively little in the literature on the ...

New product development (NPD) is crucial for a company’s success in a competitive market. Meanwhile, NPD is a process associated with great complexity and high risk. To ensure its smooth operation, risks involved in an NPD process need to be analyzed in a proper way. In this paper, a novel method is proposed to generate a belief rule base (BRB), which is the basis of the Belief Rule-Base Infere...

Customer integration is an integral element of the innovation process today. Yet, despite the potential for integrating external knowledge into new product development (NPD) processes, companies often fail to benefit sufficiently from customer integration. Research attributes this failure to restricted absorptive capacity, intellectual property concerns, or the ''not-invented-here'' syndrome bu...

New product development (NPD) in the pharmaceutical industry is very knowledge intensive. Knowledge generated and used during medical NPD processes is fragmented and distributed across various phases and artifacts. Many challenges in medical NPD can be addressed by the integration of this fragmented knowledge. We propose the creation and use of knowledge networks to address these challenges. Ba...

Background: Nasal potential difference (NPD) test has long been used to assist in the diagnosis of Cystic Fibrosis (CF) and more recently as an outcome measure in clinical trials of new CF therapies. This test has also been adapted to the mouse nose. Objectives: We aimed at evaluating variability of the NPD measurements in CF patients displaying two severe CFTR mutations and in sex-matched heal...

The activity of acyl-CoA:cholesterol acyltransferase (ACAT; EC 2.3.1.26) was measured in fibroblast homogenates from Niemann-Pick Type C (NPC) and Type D (NPD) patients to determine whether these cells exhibit similar defects in the regulation of cholesterol esterification. ACAT activity in normal cells cultured in the absence of serum lipoproteins responded rapidly (within 6 h) to the addition...

New product development (NPD) teams enhance their change of success when they process rich and diverse market information. However, processing market information in really new NPD is subject to high levels of uncertainty and often conducted under high levels of teamautonomy. Prior research focused on intra-team factors, such as cross-functional integration, affecting market information processi...

NPD teams enhance their change of success when they process rich and diverse market information in the course of a new product innovation trajectory. A large body of literature has advocated that including this information, such as insights on developments in market segments and customer needs regarding product applications, in new product decisionmaking is critical for new product performance....