The molecular chaperone binding protein (BiP) participates in the constitutive function of the endoplasmic reticulum (ER) and protects the cell against stresses. In this study, we investigated the underlying mechanism by which BiP protects plant cells from stress-induced cell death. We found that enhanced expression of BiP in soybean (Glycine max) attenuated ER stress- and osmotic stress-mediat...

RATIONALE Lymphatic vasculature plays important roles in tissue fluid homeostasis maintenance and in the pathology of human diseases. Yet, the molecular mechanisms that control lymphatic vessel maturation remain largely unknown. OBJECTIVE We analyzed the gene expression profiles of ex vivo isolated lymphatic endothelial cells to identify novel lymphatic vessel expressed genes and we investiga...

The goal of this study was to compare the effectiveness of three treatments aiming to reduce nasal airflow resistance (NR): an external nasal strip device (Respir+), an internal nasal mechanical dilator (Nozovent), and a topical decongestant (Pernazène). NR was estimated by active posterior rhinometry at both a 0.5 L/s flow (NRF) and a 1 cm H2O pressure (NRP), under four conditions: in the basa...

Nonribosomal peptides (NRPs) are produced by NRP synthetase (NRPS) enzymes that function as molecular assembly lines. The modular architecture of NRPSs suggests that a domain responsible for activating a building block could be replaced with a domain from a foreign NRPS to create a chimeric assembly line that produces a new variant of a natural NRP. However, such chimeric NRPS modules are often...

This essay traces the simultaneous development of two distinct efforts to unify brain sciences in twentieth century—one originating at Montreal Neurological Institute (MNI) and other Massachusetts Technology (MIT). Both coalesced around investigations memory but displayed profoundly different disciplinary styles. At MNI, loss surgical patients crystallized a form research that eventually became...

Background and Purpose: Cervical spinal cord injury results in specific deficits in forelimb function. In the rat, lesions to the rubrospinal tract impair forelimb function despite the presence of an intact corticospinal tract. Both functional and anatomical recovery have been promoted by transplantation of neuronal and glial restricted precursors (NRP/GRP) following injury, and task-specific p...

Background. Neuropilin-1 (NRP-1) is a multidomain membrane protein with soluble isoforms interacting with a complex network of other membrane receptors, their respective ligands and heparan sulfate (HS). It is involved in the development of vasculature, neural patterning, immunological responses and pathological angiogenesis. Methods. We have characterised the binding of a Fc fusion of rat NRP-...

BACKGROUND Childhood body mass index (BMI) and obesity prevalence have been associated with exposure to secondhand smoke (SHS), maternal smoking during pregnancy, and vehicular air pollution. There has been little previous study of joint BMI effects of air pollution and tobacco smoke exposure. METHODS Information on exposure to SHS and maternal smoking during pregnancy was collected on 3,318 ...

This paper presents an overview of recent advances for the Nurse Rostering Problem (NRP) based on methodological papers published between 2012 to 2021. It provides a comprehensive review latest solution methodologies, particularly computational intelligence (CI) approaches, utilized in benchmark and real-world nurse rostering. The methodologies are systematically categorised (Heuristics, Meta-h...