The major conjugated linoleic acid (CLA) isomers, c9,t11-CLA and t10,c12-CLA, have anticancer effects; however, the exact mechanisms underlying these effects are unknown. Evidence suggests that reversal of reduced gap junctional intercellular communication (GJIC) in cancer cells inhibits cell growth and induces cell death. Hence, we determined that CLA isomers enhance GJIC in human MCF-7 breast...

The rhizome of Dryopteris crassirhizoma has been used as a traditional herbal medicine for treating various inflammatory and infectious diseases such as tapeworm infestation and mumps. In the present study, we investigated the bone protective effect of water extract of the rhizome of Dryopteris crassirhizoma (WEDC). We found that WEDC inhibits osteoclast differentiation via directly acting on o...

OBJECTIVE Although the connection of oxidative stress and inflammation has been long recognized in diabetes mellitus, the underlying mechanisms are not fully elucidated. This study defined the role of 26S proteasomes in promoting vascular inflammatory response in early diabetes mellitus. METHODS AND RESULTS The 26S proteasome functionality, markers of autophagy, and unfolded protein response ...

Let B(κ, λ) be the subalgebra of P(κ) generated by [κ]. It is shown that if B is any homomorphic image of B(κ, λ) then either |B| < 2 or |B| = |B|, moreover if X is the Stone space of B then either |X| ≤ 2 λ or |X| = |B| = |B|. This implies the existence of 0-dimensional compact T2 spaces whose cardinality and weight spectra omit lots of singular cardinals of “small” cofinality.

The inhibitor of kappa B kinase epsilon is overexpressed in glioma and plays antiapoptotic role via activating nuclear factor-kappa B. microRNA-98 can suppress glioma, modulate the activities of nuclear factor-kappa B, and bind to the 3'-untranslated region of inhibitor of kappa B kinase epsilon messenger RNA. This study was aimed to investigate the modulation of inhibitor of kappa B kinase eps...

The well-known Chvátal–Erdős Theorem states that every graph G of order at least three with α(G) ≤ κ(G) has a hamiltonian cycle, where α(G) and κ(G) are the independence number and the connectivity of G, respectively. Oberly and Sumner [J. Graph Theory 3 (1979), 351–356] have proved that every connected, locally-connected claw-free graph of order at least three has a hamiltonian cycle. We study...