Nesfatin-1 is a recently identified anorexigenic peptide derived from its precursor protein, nonesterified fatty acid/nucleobindin 2 (NUCB2). Although the hypothalamus is pivotal for the maintenance of energy homeostasis, adipose tissue plays an important role in the integration of metabolic activity and energy balance by communicating with peripheral organs and the brain via adipokines. Curren...

Calnuc, a Golgi calcium binding protein, plays a key role in the constitution of calcium storage. Abnormal calcium homeostasis has been linked to Alzheimer's disease (AD). Excessive production and/or accumulation of beta-amyloid (Abeta) peptides that are proteolytically derived from the beta-amyloid precursor protein (APP) have been linked to the pathogenesis of AD. APP has also been indicated ...

background nesfatin-1 is a protein derived from a precursor molecule of the nucleobindin-2 gene, and acts as an anorexigenic peptide on food intake behavior, and its level isinfluenced by nutritional status, food composition [fat and carbohydrate (cho)], and physical exercise. objectives the aim of this study was to investigate the effects of 6 weeks of treadmill running (at high intensity) pro...

Seminal plasma is composed of secretions from accessory sex glands, which are mixed with sperm at ejaculation and contribute the majority of semen volume. Seminal plasma is considered a transport and support medium for sperm in the female reproductive tract. Because seminal plasma is not required for fertilization, the importance of its constituents to the establishment of normal pregnancy has ...

Background Currently, the role of tissue cytokines in pathogenesis various diseases is being actively studied [1,2]. Nesfatin-1 (NF-1) an endogenous peptide with pleiotropic activity. Recently, there have been works on involvement NF-1 osteogenesis. In experiment, intravenous administration to ovariectomized rats (OVX) leads increase bone mineral density (BMD). There are showing inhibition oste...

Reinhardt, Timothy A., Ronald L. Horst, and W. Ray Waters. Characterization of Cos-7 cells overexpressing the rat secretory pathway Ca -ATPase. Am J Physiol Cell Physiol 286: C164–C169, 2004. First published September 10, 2003; 10.1152/ajpcell.00065.2003.—On the basis of sequence similarities to the yeast PMR1 and hSPCA gene, the rat alternatively spliced mRNA has been suggested to be a Golgi s...

Insulin resistance and declining insulin production define a spectrum of metabolic diseases afflicting a growing portion of the population (1). Current estimates suggest that 26 million Americans have diabetes, with the incidence of type 2 diabetes involving insulin resistance and b-cell decompensation far exceeding that of type 1 diabetes. Treatment of type 2 diabetes involves secretagogues th...