OBJECTIVE Among adults with type 2 diabetes (T2D), several (but not all) studies show that being overweight (body mass index (BMI): 25.0-29.9 kg/m2) or obese I (BMI: 30.0-34.9 kg/m2) near the time of diagnosis, is unexpectedly associated with reduced all-cause mortality compared with normal weight-the obesity paradox. We addressed whether this observation is causal (eg, a true protective effect...

n the Editorial Comment by Lavie and Milani (1) accompanying he report by Reeves and associates (2), the correspondents used as heir title “Obesity and Cardiovascular Disease: The Hippocrates aradox?”. Lavie and Milani began their comment by quoting a tatement by Hippocrates, namely, “Sudden death is more comon in those who are naturally fat than in the lean.” Clearly ippocrates recognized the ...

BACKGROUND Obesity paradox is defined as the unexpected decrease in the total number of death which has been observed among patients who are overweight and obese compared to patients with normal weight after undergoing revascularization by percutaneous coronary intervention (PCI). Despite of so many recent studies which showed the existence of this phenomenon, prolonged and intensive medication...