A closed colony of semi-free-ranging rhesus monkeys maintained in isolation since 1938 by the Caribbean Primate Research Center (CPRC) is being studied as a model for age related macular drusen. Of examined colony animals 57.7% of the monkeys and 47.3% of their eyes have drusen. The prevalence and severity of drusen are linearly related to increasing age and are significantly higher in specific...

Background: We have recently shown that human embryonic (hESCs) and induced pluripotent stem cells (hiPSCs) can differentiate into advanced spermatogenic cells including round spermatids by in vitro culture (Easley et al., Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Reports 2, 440-446 2012) and also, in collaboration, that rhesus spermatogonial ...

Humans can remember where in space they have seen an object. In this example of one-trial event or episodic memory, an association must be formed between an object and a place ‘‘out there,’’ and the place can be recalled with the object as a recall cue, or the object can be recalled with the place as a recall cue. Hippocampal spatial view neurons in primates provide allocentric representations ...

In this paper, we address multiple motion analysis from the standpoint of orientation analysis. Using the fact that multiple motions are equivalent to multiple planes in the derivative space or in the spectral domain, we apply a new kind of 3D steerable filter in motion estimation. This new method is based on the decomposition of the sphere with a set of overlapping basis filters in the feature...

Accurate human posture estimation from single or multiple images is essential in many applications. Two main causes of difficulty to solve the estimation problem are large number of degrees of freedom and self-occlusion. Treestructured graphical models with efficient inference algorithms have been used to solve the problem in a lower dimensional state space. However, such models are not accurat...

dioxide on bronchoconstriction after pulmonary artery occlusion. Am J Physiol214: 772-775, 1968 33. Severinghaus JW, Stupfel MJ: Alveolar dead space as an index of distribution of blood flow in pulmonary capillaries. J Appl Physiol 10:335-348, 1957 34. Severinghaus JW, Swenson EW, Finley TN, Lategola MT, Williams J: Unilateral hypoventilation produced in dogs by occluding one pulmonary artery. ...

BACKGROUND Most experimental stroke research is carried out in rodents, but given differences between rodents and human, nonhuman primate (NHP) models may provide a valuable tool to study therapeutic interventions. The authors developed a surgical method for transient occlusion of the M1 branch of middle cerebral artery (MCA) in the African green monkey to evaluate safety aspects of intravenous...

Wild primates face significant challenges associated with locating resources that involve learning through exploration, encoding, and recalling travel routes, orienting to single landmarks or landmark arrays, monitoring food availability, and applying spatial strategies that reduce effort and increase efficiency. These foraging decisions are likely to involve tradeoffs between traveling to near...

Splatting is an object-order volume rendering algorithm that produces images of high quality, and several optimization techniques have been proposed. This paper presents new techniques that accelerate splatting algorithms by exploiting both object-space and image-space coherence. In particular, we propose two visibility test methods suitable for octree-based splatting. The rst method, based on ...

Mirror neurons, located in the premotor cortex of macaque monkeys, are activated both by the performance and the passive observation of particular goal-directed actions. Although this property would seem to make them the ideal neural substrate for imitation, the puzzling fact is that monkeys simply do not imitate. Indeed, imitation appears to be a uniquely human ability. We are thus left with a...