Background: Currently, radiotherapy represents the most widely employed therapeutic option in patients with uveal melanoma. Although effects of proton beam on melanoma end ocular tissues have been histologically documented, their appearance at MR imaging is still poorly understood. The purpose our study was to elucidate magnetic resonance (MR) semiotics radiotherapy-induced changes neoplastic a...

Recent advances have suggested that long noncoding RNAs (lncRNAs) are differentially expressed in ocular tissues and play a critical role in the pathogenesis of different types of eye diseases. Here, we summarize the functions and mechanisms of known aberrantly-expressed lncRNAs and present a brief overview of relevant reports about lncRNAs in such ocular diseases as glaucoma, proliferative vit...

Since Mullerian Inhibiting Substance (MIS) causes regression of the Mullerian duct, the anlagen of the uterus, vagina, and fallopian tube, we expected and have previously observed that purified recombinant human MIS causes regression of gynecological tumors. However, recent experiments indicating that neural crest derivatives might be responsive to MIS prompted study of a group of human ocular ...

Orbital tumors are an infrequent disease in our environment, the etiology of which could be primary to the orbit or secondary. The most frequent tumors are lymphomas which, according to several publications, account for 11% of orbital tumors and 55% of malign tumors.1 These slow-growing tumors can be silent2 or could generate reversible ocular lesions such as compressive neuropathy, accompanied...

role of the protein overexpression is very important in the pathogenesis, diagnosis and prognosis of neoplasia. cases of overexpression of p53 and ki67 proteins were investigated in 19 ocular squamous cell carcinomas (oscc) in dairy cows. microscopically, insix cases the tumors were carcinoma in situ (noninvasive carcinoma, g0), and in the remaining 13 cases the tumors were invasive carcinoma. ...

Orbital tumors are that occur in the orbital area where they can affect outside of orbit and inside orbit. At present, it is still rare to report prevalence world. In developing countries such as Indonesia, reports on incidence also rarely reported. Diagnosis appropriate therapy if we recognize characteristics these tumors. The purpose this study was determine tumor patients at PMN Cicendo Eye ...

Ocular metastasis of renal cell carcinoma is rare, and metastasis to the iris or ciliary body is especially uncommon. Ferry and Font studied 227 cases of metastatic tumors of the eye and orbit and reported that 26 (11.5%) of these lesions were iris or ciliary body tumors and that 2 (0.9%) originated in the kidney. We examined a patient with an iris tumor that metastasized from a renal cell carc...

Purpose: We report an unusual case of trabecular carcinoid of the ovary with orbital involvement. Methods: We encountered a 49-year-old woman with a complaint of bilateral proptosis. Ocular examination revealed severe bilateral proptosis and signs of corneal exposure. Orbital CT scan showed massive enlargement of extraocular muscles and optic nerve compression. The patient medical history showe...

PURPOSE A line of transgenic mice containing the simian virus (SV) 40 T-antigen (T-ag) gene driven by the beta-luteinizing hormone (BLH) promoter developed bilateral retinoblastoma and primitive neuroectodermal tumors (PNET) of the midbrain. Midbrain tumors arose from the subependymal layer of the cerebral aqueduct. Bilateral ocular and brain tumors ("trilateral") were found in three other SV40...

PURPOSE Choroidal melanoma is the most common primary malignant ocular tumor in human adults. Relevant mouse models of human uveal melanoma still remain to be developed. We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melan...