نتایج جستجو برای: offspring rat
تعداد نتایج: 305956 فیلتر نتایج به سال:
BACKGROUND Excessive androgen exposure during pregnancy has been suggested to induce diabetic phenotypes in offspring in animal models. The aim of this study was to investigate whether pregestational maternal hyperandrogenism in human influenced the glucose metabolism in offspring via epigenetic memory from mother's oocyte to child's somatic cells. METHODS Of 1782 reproductive-aged women dete...
OBJECTIVE(S) Epilepsy is a neurodevelopmental disorder which is strongly influenced by genetic and environmental factors. Gestational stress has been shown to be an important factor for affecting seizure susceptibility. The present study was conducted to address whether gestational stress may affect pentylentetrazol (PTZ)-induced epileptic behavior in rat offspring in a sex- and age- dependent ...
We examined the effect of prenatal ethanol exposure on gamma-aminobutyric acid (GABA)-stimulated 36Cl- flux. Sprague-Dawley rat dams were fed either a liquid diet containing 5% ethanol, pair-fed an isocalorically equivalent 0% ethanol diet or rat chow ad libitum throughout gestation. Membrane vesicles were prepared from medial frontal cortex, cerebellum and hippocampal formation of adult offspr...
Low birth weight is a risk factor for the subsequent development of hypertension in humans. We previously reported that reduced uterine perfusion in the pregnant rat results in growth-restricted offspring predisposed to the development of hypertension. The purpose of this study was to determine whether the sympathetic nervous system plays a role in mediating hypertension in this model of low bi...
To assess the neurotoxic effects and redox responses of Aroclor 1254 (A1254) on perinatally exposed rat offspring, A1254 was administered by gavage from gestational day (GD) 6 to postnatal day (PND) 21. Neurobehavioral development, antioxidant enzyme activities, lipid peroxidation (LPO), nitric oxide (NO), and NO synthase (NOS) levels were analyzed in the offspring. Neurobehavioral development ...
Abstract Aberrant neuronal network activity likely resulting from disturbed interactions of excitatory and inhibitory systems may be a major cause cognitive deficits in neuropsychiatric diseases, like within the spectrum schizophrenic phenotypes. In particular, synchrony pattern oscillatory brain appears to limbic networks, e.g. between prefrontal cortex hippocampus. rat model maternal immune a...
The development of polycystic ovary syndrome (PCOS) is closely related to the chronic inflammatory and obese. Recent studies have found macrophages regulate inflammation adipose tissue remodelling, but underlying mechanisms not been clarified. In this study, we established a model PCOS in offspring rats by high androgen exposure during late pregnancy parental female rat macrophage eliminating r...
Leptin is involved in regulating food intake, energy balance and bone formation. Increasing evidence suggests that leptin is also involved in fetal growth and development. The aim of this study was to determine if increased maternal leptin is followed by changes in body composition, skeletal growth or hormonal regulation in the adult rat offspring. Pregnant rats were given injections of either ...
The rates of gestational cannabis use have increased despite limited evidence for its safety in fetal life. Recent animal studies demonstrate that prenatal exposure to ?9-tetrahydrocannabinol (?9-THC, the psychoactive component cannabis) promotes intrauterine growth restriction (IUGR), culminating postnatal metabolic deficits. Given IUGR is associated with impaired hepatic function, we hypothes...
امروزه برهم کنش میان سیستم های گلوتاماتی و کانابینوئیدی در برخی از نواحی مغزی مرتبط با حافظه به اثبات رسیده است. بنظر می رسد که هسته آکومبنس با داشتن جایگاهی در مرکز مدارهای نورونی سیستم لیمبیک نقش یکپارچه سازی و تثبیت اطلاعات ورودی از سایر بخش های مغز را برعهده دارد. در این مطالعه، اثرات ناشی از تزریق آگونیست و آنتاگونیست رسپتورهای کانابینوئیدی (cb1) و گلوتاماتی (nmda) به ناحیه پوسته آکومبنس د...
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