To determine the developmental trajectory of hippocampal function in rats, we examined 24-h changes in extracellular acetylcholine (ACh) levels and contextual learning performance. Extracellular ACh significantly correlated with spontaneous behavior, exhibiting a 24-h rhythm in juvenile (4-week-old), pubertal (6-week-old), and adult (9- to 12-week-old) rats. Although juveniles of both sexes exh...

introduction: developmental changes in atrioventricular nodal conduction time and refractoriness have been shown in several studies. prevalence of atrioventricular nodal reentrant tachycardia (avnrt) is clearly age-dependent. the purpose of this study was to determine developmental changes of basic and frequency-dependent electrophysiological properties of the atrioventricular node (av-node) in...

Acetate oxidation was examined by (13)C nuclear magnetic resonance in skeletal muscle from adult and old rats. Rats fasted for 5 days were perfused with [2-(13)C]acetate over 2 h, and muscle extracts were analyzed for [(13)C]glutamate isotopomers. This study shows that approximately 80 % of acetyl-coenzyme A entering the tricarboxylic cycle was derived from substrate infusion in both adult and ...

Background. Cystic hygroma (CH), occurs in 1/6000 live births and 90% of cases develops age less than 2 years old. They are mainly located cervicofacial region. Adult-onset CH is very rare. Objective. The aim this study to review literature discuss the clinical presentation, diagnosis, treatment adults through a case report unilocular axillary region an adult male from India. Methods. A first I...

Comparison of Clinical Manifestations and Outcome of Community-Acquired Bloodstream Infections Among the Oldest Old, Elderly, and Adult Patients: Erratum In the article BComparison of Clinical Manifestations and Outcome of Community-Acquired Bloodstream Infections Among the Oldest Old, Elderly, and Adult Patients’’ by Lee et al, appearing inMedicine (Baltimore), Volume 86, No. 3, on page 138, t...

A diet containing adequate amounts of protein rapidly suppresses myofibrillar protein degradation after refeeding in young rats and mice. However, it is unclear whether this suppression is seen in adult animals. This study was undertaken to compare dietary protein-induced suppression of myofibrillar protein degradation in young and adult mice. Reductions in rates of myofibrillar protein degrada...

The heavy chain of myosin can be detected in human red cell membranes by immunoblot analysis with antiplatelet myosin antibodies. Neonatal red cell membranes have more immunoreactive myosin than adult membranes. Membranes from young adult red cells contain more immunoreactive myosin than membranes from old adult red cells. In contrast, young and old neonatal red cells have equivalent mounts of ...

Oxidative modification of cellular components may contribute to tissue dysfunction during aging. In skeletal muscle, contractile activity increases the generation of reactive oxygen and nitrogen species (ROS). The question of whether contraction-induced ROS generation is further increased in skeletal muscle of the elderly is important since this influences recommendations on their exercise part...

With aging there is a decline in the number of newly generated neurons in the dentate gyrus of the hippocampus. In rodents and tree shrews, this age-related decrease in neurogenesis is evident long before the animals become aged. No previous studies have investigated whether primates exhibit a similar decline in hippocampal neurogenesis with aging. To investigate this possibility, young to midd...