the most recent studies have explained almost 2.3 million children are affected with hiv up to the end of 2009. sub-saharan africa is the main region to at least 68% of the global total of hiv infection of 22.5 million. despite providing competent healthcare services to prevent mother-to-child transmission which is the main way of infection to a newborn, an estimated 370,000 children were newly...

Being the most common cause of dementia, AD is a polygenic and neurodegenerative disease. Complex and multiple factors have been shown to be involved in its pathogenesis, of which the genetics play an indispensable role. It is widely accepted that discovery of potential genes related to the pathogenesis of AD would be of great help for the understanding of neurodegeneration and thus further pro...

BACKGROUND The objective of this study was to analyze factors influencing the risk and timing of Alzheimer's disease (AD) in central Norway. The APOE epsilon4 allele is the only consistently identified risk factor for late onset Alzheimer's disease (LOAD). We have described the allele frequencies of the apolipoprotein E gene (APOE) in a large population of patients with AD compared to the frequ...

OBJECTIVES To identify novel loci for late-onset Alzheimer disease (LOAD) in Caribbean Hispanic individuals and to replicate the findings in a publicly available data set from the National Institute on Aging Late-Onset Alzheimer's Disease Family Study. DESIGN Nested case-control genome-wide association study. SETTING The Washington Heights-Inwood Columbia Aging Project and the Estudio Famil...

In the 17 years since the original report linking the 4 allele of the apolipoprotein E (APOE) gene [1] with late-onset Alzheimer’s disease (LOAD), considerable effort has been expended to elucidate the role that APOE plays in LOAD risk and age of disease onset. LOAD is a genetically complex and heterogeneous disorder. The disease has a strong heritability that is estimated to reach nearly 80% [...

In this study, an extended stress-based forming limit diagram (FLD) for prediction of necking based on the Marciniak and Kucznski (M-K) model is represented and applied in tube hydroforming. The bulge forming of a straight tube is simulated by finite element method and verified with published experimental data. This adaptive simulation technique is based on the ability to detect the onset an...