Several CGHC motif-containing disulfide isomerases support thrombosis. We here report that endoplasmic reticulum protein 72 (ERp72), with 3 CGHC redox-active sites (ao, a, and a'), supports thrombosis. We generated a new conditional knockout mouse model and found that Tie2-Cre/ERp72fl/fl mice with blood and endothelial cells lacking ERp72 had prolonged tail bleeding times and decreased platelet...

Java has, undoubtedly, received unprecedented hype. This article examines Java in light of the Object-Oriented (OO for short) paradigm. We investigate whether the hype or part of it is due to the OO features, or due to other features of the language. For that purpose, we compare Java with other major OO languages such as C++, Eiffel and Smalltalk. Furthermore, we evaluate Java to arrive at an u...

The hydrogen-bonded arene ruthenium metalla-rectangle, [(p-cymene)2Ru2(OO∩OO)(UPy)2]2(4+), obtained from 1-(4-oxo-6-undecyl-1,4-dihydropyrimidin-2-yl)-3-(pyridin-4-ylmethyl)urea (UPy) and the dinuclear arene ruthenium clip (p-cymene)2Ru2(OO∩OO)Cl2 (OO∩OO = 2,5-dioxido-1,4-benzoquinonato), is investigated by means of solution-phase NMR spectroscopy. Rotating frame nuclear Overhauser effect measu...

This paper studies testing in an object-oriented (OO) development process. It is based on the production cell case study. A control program for the production cell has been developed using both the Fusion method, for OO analysis and design, and the formal notation CO-OPN, as an intermediate between the OO design and an implementation in Ada 95. The paper describes the application of a statistic...

A good methodology should be an accurate description of sound software engineering (SE) practice. Without empirically-supported method-ologies, we run the risk of using potentially inaccurate prescriptions of the software engineering process. We reject arguments that SE is unmeasurable. Related fields, such as knowledge acquisition, routinely perform repeatable experiments on specification deve...

A series of cationic metalla-rectangles of the general formula [(p-cymene)(4)Os(4)(OO[intersection]OO)(2)(N[intersection]N)(2)](4+) have been obtained in methanol from the dinuclear arene osmium precursors [(p-cymene)(2)Os(2)(OO[intersection]OO)(2)Cl(2)] (OO[intersection]OO = 2,5-dioxydo-1,4-benzoquinonato (dhbq), 2,5-dichloro-1,4-benzoquinonato (dcbq)) by reaction with bipyridine linkers (N[in...

We believe that the OO model is a useful heuris-tic view for large networks of interdependent attributes. The mistake of the OO modeling world is to assume that this view should be actual architecture of the software. We will argue that the OO model needs to import numerous concepts from the data modeling literature. Once incorporated, the OO model would become a view of some underlying network...

We describe a framework for the development of production rule programs on top of OWL ontologies, following a hybrid Object-Oriented (OO) approach. The hybrid nature is realized by separating ontologies and rules, interfacing an external DL reasoner and a production rule engine. The OO nature is realized by mapping OWL ontologies into the OO model, in such a way, so to preserve the extensional ...

Traditionally, undergraduate students are exposed to the concepts of Object-Oriented (OO) paradigm through OO programming (OOP) courses (e.g. Early Objects courses). These courses, however, have little, if any, emphasize on developing students’ analysis and design skills. In this position paper, we first argue for the need of exposing students to basic concepts of OO analysis and designs in ear...

Faktor genetik pada pewarisan bobot hidup ternak adalah nilai pemuliaan, deviasi dominansi dan heritabilitas. Penelitian ini bertujuan mengidentifikasi komponen genotipe pemuliaan serta heritabilitasnya sapi Peranakan Ongole Lokal. Total 74 induk generasi awal (G0), 104 1 (G1) dari pejantan dianalisis kontribusi genetik. Lokus gen (gen O) Lokal L) hasil pengukuran OO, LL LO melalui dominan gen....