t d t d b SUMMARY 1. Physicians should inform cancer patients about options for fertility preservation and future reproduction prior to treatment. 2. The only established methods of fertility preservation are sperm cryopreservation in men and embryo cryopreservation in women. 3. Experimental procedures such as oocyte or ovarian tissue cryopreservation should be offered only in a research settin...

t d t d b SUMMARY 1. Physicians should inform cancer patients about options for fertility preservation and future reproduction prior to treatment. 2. The only established methods of fertility preservation are sperm cryopreservation in men and embryo cryopreservation in women. 3. Experimental procedures such as oocyte or ovarian tissue cryopreservation should be offered only in a research settin...

BACKGROUND A successful oocyte cryopreservation programme is of utmost importance where a limited number of oocytes can be inseminated per cycle, to overcome legal and ethical issues related to embryo storage, for oocyte donation programmes and for fertility preservation (especially for cancer patients). Vitrification has been recently proposed as an effective procedure for this purpose. METH...

BACKGROUND An alginate-based matrix supports the three-dimensional (3D) architecture of non-human primate follicles and, in the presence of FSH, permits the in vitro development of pre-antral follicles to the small antral stage, including the production of ovarian steroids and paracrine factors. The current study investigated the ability of gonadotrophins, fetuin and oxygen (O₂) to improve prim...

The stage at which follicle-enclosed cumulus-oocyte complexes achieve developmental competence in primates is unknown. Therefore, studies were designed to characterize the ability of oocytes in small antral follicles present during the menstrual cycle to spontaneously resume meiosis, fertilize, and support early embryo development. Ovaries were removed from adult rhesus monkeys (n = 12) during ...

An option for fertility preservation for women facing a cancer diagnosis involves the cryopreservation of ovarian tissue for later re-transplantation or in vitro culture, with in vitro culture preferred to avoid reintroduction of the cancer. Small, immature follicles survive the freeze-thaw process, and can be matured through in follicle maturation (IFM) that involves an initial growth of the f...

Glioblastoma (GBM) is a malignant brain tumour with poor prognosis. The potential pathogenesis and therapeutic target are still need to be explored. Herein, TCGA expression profile data clinical information were downloaded, the WGCNA was conducted. Hub genes which closely related prognosis of GBM obtained. Further, relationship between interest GBM, immune microenvironment analysed. Patients fr...

background: testis tissue xenografting and the resultant sperm in a xenograft may provide a unique approach to rescue the genetic material of males that die prematurely and is a model for the study of human spermatogenesis and can represent an alternative approach for fertility preservation in cancer patients. this study was aimed to evaluate the xenogenic dog sperm in formation of male pronucl...