Since last three decades delivery of the desired drug as muocoadhesive drug delivery systems has been subject of interest. Mucoadhesion involving a polymeric drug delivery system is a complex phenomenon that includes theory of diffusion, wetting, adsorption, fracture and interpenetration of polymer chains amongst various other processes. Various polymer-based properties such as the degree of cr...

In current drug delivery scenario, despite numerous scientific efforts, efficient ocular drug delivery remains a challenge for pharmaceutical scientists. In ocular drug delivery system, ocular infections are treated by various topical drug applications in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability due ...

Gelation of pectin caused by divalent cations especially calcium ions has been applied to develop an ophthalmic formulation of azithromycin in the present study. Rapid elimination of drug on instillation into cul de sac would be minimal with in situ gelling ophthalmic solution leading to increased precorneal contact time and prolonged drug delivery. In the formulation development studies pectin...

Controlled and sustained delivery of ophthalmic drugs continues to remain a major focus area in the field of pharmaceutical drug delivery with the emergence of new, more potent drugs and biological response modifiers that may also have very short biological half-lives. The present review was conducted on drug delivery to the ocular route. Polymers with suitable rheological properties can facili...

PURPOSE StarGen is an equine infectious anemia virus (EIAV)-based lentiviral vector that expresses the photoreceptor-specific adenosine triphosphate (ATP)-binding cassette transporter (ABCA4) protein that is mutated in Stargardt disease (STGD1), a juvenile macular dystrophy. EIAV vectors are able to efficiently transduce rod and cone photoreceptors in addition to retinal pigment epithelium in t...

Introduction: The development of ophthalmic formulations able to deliver hydrophilic and hydrophobic drugs the inner structures eye restore preocular tear film has been a leading topic discussion over last few years. In this sense, liposomes represent suitable strategy achieve these objectives in ocular drug delivery.Areas covered: Knowledge different physiological anatomical structures, specia...