AIMS To determine the effectiveness and safety of three wall orbital decompression by the coronal approach in Graves' ophthalmopathy. METHODS The records of 125 patients with Graves' ophthalmopathy, who had undergone three wall orbital decompression by coronal approach between April 1984 and October 1993, were studied retrospectively. Special attention was paid to proptosis reduction, changes...

Graves’ ophthalmopathy is a debilitating disease impairing the quality of life of the affected individuals. Despite recent progress in the understanding of its pathogenesis, treatment is often not sa ­ tisfactory. In mild cases, local therapeutic measures (artificial tears and ointments, sunglasses, nocturnal eyes taping, prisms) can con­ trol symptoms and signs. In severe forms of the disease,...

background: killer cell immunoglobulin-like receptors (kir) are expressed on nk cells and a subset of t cells. the variable kir receptors along with their ligands, hla class i, influence risk for autoimmune and malignant diseases. objective: to investigate the kir gene profiles in relation to susceptibility to graves’ disease in patients with ophthalmopathy. methods: kir genes profiles were ana...

Background Inflammation of the orbital connective tissue, extraocular muscles and upper eyelids occurs in about 40% of patients with Graves hyperthyroidism [Graves Ophthalmopathy (GO)] while mild eye signs including upper eyelid retraction are found in as many as 25% of patients with Hashimoto thyroiditis and, occasionally, transient thyroiditis. Some workers have proposed a relationship betwee...

The purpose of the study was to evaluate the percentage of CD4+/CD8+ peripheral T cells expressing CD62L+ and CD54+ in patients with Graves' disease and to assess if these estimations could be helpful as markers of active ophthalmopathy. The study was carried out in 25 patients with Graves' disease (GD) divided into 3 groups: 1/ 8 patients with active Graves' ophthalmopathy (GO) (CAS 3-6, GO co...

OBJECTIVE The aim of this study is to evaluate the response rate of hyperthyroidism to radioactive iodine (RAI) treatment, optimum effective dose, effect of pretreatment with thyrostatic medications, etiology, ophthalmopathy, mortality and cancer incidence post RAI treatment. METHODS Retrospective study analysis of 360 patients records who received RAI treatment (dose 5-15 mCi) for hyperthyro...

PURPOSE To assess quality of life and depressive status in Korean patients with Graves' ophthalmopathy. METHODS A cross-sectional study of 49 patients (mean age, 41 years; sex ratio, M:F=11:38) with Graves' ophthalmopathy (referred to as the Graves' group) and 48 age-matched and sex-matched controls (mean age, 40.2 years; sex ratio, M:F=11:37) was performed using the Korean version of the 36-...

Clinical aspects, laboratory investigation, and treatment of hyperthyroidism and hypothyroidism are reviewed in light of recent information. Special circumstances, such as hyperthyroidism during pregnancy, Graves ophthalmopathy, iodine-induced hyperthyroidism, and subclinical hypothyroidism, are also considered.

Abstract Introduction The impact of thyroidectomy for Graves’ disease (GD) on ophthalmopathy (GO) is not well understood. It generally accepted that does exacerbate or precipitate GO in the majority. aim this study was to evaluate whether prophylactic glucocorticoid use following total GD prevents early post-operative reactivation GO. Methods A retrospective cohort covering 5 years, studying pa...