نتایج جستجو برای: opioid substance
تعداد نتایج: 236027 فیلتر نتایج به سال:
The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human genetic studies of addiction. Because of its potential functional significance, the non-synonymous variant rs1799971 (A118G, Asn40Asp) in OPRM1 has been extensively studied, yet its role in addiction has remained unclear, with conflicting association findings. To resolve the question of what effect, if any, r...
Noradrenaline (NA), a key neurotransmitter of the endogenous pain inhibitory system, acutely inhibits nociceptive transmission (including that mediated by substance P), potentiates opioid analgesia, and underlies part of the antinociceptive effects of the widely prescribed tricyclic antidepressants. Lesions of noradrenergic neurons, however, result in either normal or reduced pain behavior and ...
BACKGROUND While a number of pharmacological interventions exist for the treatment of opioid use disorder, evidence evaluating the effect of pain on substance use behavior, attrition rate, and physical or mental health among these therapies has not been well established. We aim to evaluate these effects using evidence gathered from a systematic review of studies evaluating chronic non-cancer pa...
BACKGROUND The growing trends in opioid abuse, assessment of the abuse liability of prescription opioid products, and growing efforts by the pharmaceutical industry to develop 'abuse-resistant' formulations highlight a need to understand the features that make one product more 'attractive' than another to potential abusers. We developed a scale to measure the 'attractiveness' of prescription op...
Drug use remains endemic among the incarcerated populations. There are especially strong links between between opioid use and crime. Several models have been proposed to explain the complex nature of this relationship. Various factors e.g. street culture and socio-demographic profile may modify the relationship between opioid use and crime. The article will provide an overview of substance use ...
Certain groups with preexisting mental and behavioral health conditions, such as substance use disorders, may be especially vulnerable during and shortly after disasters. Researchers have found that substance abuse treatment programs and the individuals they serve experienced major disruptions after the September 11, 2001, attacks on the World Trade Center and the Pentagon and after Hurricane K...
Substance use disorders are a leading cause of morbidity and mortality in the United States. Medications for the treatment of substance use disorders are effective yet underutilized. This article reviews recent literature examining medications used for the treatment of alcohol and opioid use disorders. The neurobehavioral rationale for medication treatment and the most common ways medications w...
Emergency department (ED) rates for mental health conditions, substance abuse and opioid overdose in 2020 exceed over the same time period examined 2019, according to new research published online first JAMA Psychiatry. The Centers Disease Control Prevention (CDC) determined this project be public surveillance rather than that involved human subjects.
Opioids are a mainstay in acute pain management and produce their effects side (e.g., tolerance, opioid-use disorder immune suppression) by interaction with opioid receptors. I will discuss pharmacology some controversial areas of enquiry anaesthetic relevance. The main target is the µ (mu,MOP) receptor but other members family, δ (delta; DOP) κ (kappa; KOP) receptors also analgesic actions. Th...
The challenge of addressing the epidemic of opioid overdose in Rhode Island, and nationwide, is only possible through collaborative efforts among a wide breadth of stakeholders. This article describes the range of efforts by numerous partners that have come together to facilitate community, and treatment-related approaches to address opioid-involved overdose and substance use disorder. Strategi...
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