Background: Squamous Cell Carcinoma (SCC) of the tongue constitutes about 25% - 40% oral carcinomas. Most often, treatment failure occurs as local and regional recurrences. Currently, collection Lingual Lymph Nodes (LLNs) that are located on floor mouth has gained more attention. The lingual lymph nodes inconstant para intermediate appearing along course lymphatic vessels mouth. aim was to asse...

OBJECTIVE To present a rare case of breast carcinoma initially presenting as an oral cavity mass. STUDY DESIGN Case report with review of the literature. RESULTS A case is presented of a postmenopausal woman with a remote history of treated breast carcinoma who was declared disease-free 2 years before presentation. She presented with an enlarging vestibule mass consistent with metastatic br...

Heat-shock protein 90 (HSP90) is a major cellular chaperone protein. HSP90 supports the correct conformation, stabilization, activation, and localization of 'client' oncoproteins, many of which are involved in tumor progression. Therefore, the use of HSP90 inhibitors has become a new strategy in antitumor therapy. However, the effects of an HSP90 inhibitor on oral squamous cell carcinoma are st...

Background The oral squamous cell carcinoma (OSCC) is a malignant neoplasm originating from the epithelial lining of the oral cavity, accounting for about 95% of malignant lesions in this region. In Brazil, the oral cavity is the fifth location of the highest incidence of cancer in men and the seventh in women. In 2012, Brazil was estimated at 9,990 new cases of oral cancer in men and 4,180 in ...

Inhaled or chewed tobacco is equally addictive and harmful and used daily by over 1 billion people. In addition to increased rates of coronary artery disease, stroke, peripheral vascular disease, congestive heart failure, chronic obstructive pulmonary disease and lung cancers, tobacco is the leading preventable cause of oral cavity squamous cell carcinoma. In addition to tobacco, consumption an...

Fibroblast growth factor receptor 3 (FGFR3) is a member of the fibroblast growth factor receptor tyrosine kinase family. It has been identified as a promising therapeutic target in multiple types of cancer. We have investigated FGFR3 protein expression and FGFR3 gene copy-numbers in a single well-documented cohort of oral and oropharyngeal squamous cell carcinoma. Tissue microarray sets contain...

Of all Cancers, Oral cancer is one of the most typical cancers in world. has delayed clinical detection, poor prognosis, without specific biomarkers, and expensive therapeutic methods. This study aims to explain basic aspects oral focuses on squamous cell carcinoma cavity. The duration detection depends amount tobacco usage individual. In this study, we have presented stochastic models for onse...

Background and Aim: Oral lichen planus (OLP) is a chronic mucocutaneous disease, which is considered a precancerous condition. OLP is a multifactorial disease with no conclusive treatment. Timely diagnosis and treatment of oral lesions are necessary steps to prevent malignant transformations and severe complications of oral cancer. This study aimed to evaluate the frequency and severity of mali...

S phase kinase-interacting protein 2 (Skp2), an F box protein, is required for the ubiquitination and consequent degradation of p27. It is well known that reduced expression of p27 is frequently observed in various cancers including oral squamous cell carcinoma and is due to an enhancement of its protein degradation. Our previous study showed that overexpression of Skp2 was frequently found in ...

Oral squamous cell carcinoma is rare in the pediatric population. When it does occur, it is most commonly seen on the tongue or lip. In this article, we report a rare case of squamous cell carcinoma of the maxillary gingiva and alveolus in a 10-year-old girl and review the literature concerning oral squamous cell carcinoma in the pediatric population.