OBJECTIVE To determine the prevalence, clinical characteristics, management methods and prognosis of testicular cancer at Kenyatta National Hospital. DESIGN Retrospective case study of testicular cancer patients over a fifteen year period. SETTING Kenyatta National Hospital, a referral and teaching hospital. PARTICIPANTS All histologically confirmed testicular cancer patients recorded at ...

Over the past few decades, the cardiovascular benefits of a high dietary intake of long-chain polyunsaturated fatty acids (PUFAs), like docosahexaenoic acid (DHA), have been extensively studied. However, many of the molecular mechanisms and effects exerted by PUFAs have yet to be well explained. The lack of sex hormones alters vascular tone, and we have described that a DHA-supplemented diet to...

The role of gonadal hormones in induction and, particularly, maintenance/progression of rat thymic involution, which normally starts around puberty, was reassessed by examining the effects of peripubertal orchidectomy on thymic weight and morphometric parameters at different times up to the age of 10 months. Up to 6 months post-castration both thymic weight and cellularity in orchidectomized (C...

Aromatization of androgens into estrogens may explain some of the skeletal action of androgens. We examined the effect of the aromatase inhibitor Vorozole (VOR) on skeletal growth and mineral accumulation in growing 6-week-old male Wistar rats. Rats were either Sham-operated (Sham) or Orchidectomized (Orch) and treated with or without the aromatase inhibitor VOR. One Sham-operated group was kil...

Abstract Background Testicular rupture refers to injury of the tunica albuginea and subsequent extrusion seminiferous tubules. It occurs usually in young men following high impact or sporting injuries. Prompt diagnosis is required, treatment time-critical avoid testicular loss. Clinical scenario A 32-year-old man presented emergency department with scrotal pain five hours after a direct blow ri...

Abstract Aim Assess the proportion of patients undergoing: (1) Preoperative assessment testicle, including serum tumour markers (STM) and testicular ultrasound (US), (2) Orchidectomy within 3 weeks US diagnosis, (3) Radiological staging (CT) surgery. Method Patients who had a radical inguinal orchidectomy for probable malignancy were identified, between January October 2021, via electronic thea...

PURPOSE To assess the patterns of use of androgen deprivation therapy (ADT) and chemotherapeutic agents in New Zealand men with prostate cancer. METHODS Men diagnosed with prostate cancer between 2006 and 2011 were identified from the New Zealand Cancer Registry. Through data linkage with the Pharmaceutical Collection and the National Minimum Dataset information on subsidised anti-androgens, ...

Rise in incidence and variable natural history of prostatic carcinoma, presents a challenge to professionals involved in its management. Cases that come for evaluation and treatment in developing countries like ours are elderly and usually present in the late stages of the disease. Perhaps the best option remain at this stage is palliative in the form of channel TURP to improve the urine flow a...