Severe intraabdominal infection associated with abdominal wall, intraperitoneal and remote organ complications, still carries an unacceptably high morality rate. In addition to the fundamental principle of eradication of the source of infection, various treatment modalities have been suggested to improve the commonly grave outcome. Amongst these, open management (OM) of the septic abdomen,...

CONTEXT Thrombocytopenia associated multiple organ failure is a rare but increasingly recognized condition in children. Diabetic ketoacidosis preceding thrombocytopenia associated multiple organ failure is previously unreported in pediatric patients. CASE REPORT A 12-year-old female presented with diabetic ketoacidosis along with acute pancreatitis. She further developed thrombocytopenia and ...

INTRODUCTION Microvascular dysregulation characterized by hyporesponsive vessels and heterogeneous bloodflow is implicated in the pathogenesis of organ failure in sepsis. The renin-angiotensin system (RAS) affects the microvasculature, yet the relationships between RAS and organ injury in clinical sepsis remain unclear. We tested our hypothesis that systemic RAS mediators are associated with dy...

Critically ill patients with multi-organ failure are especially susceptible to problems with skin integrity, including skin failure. An 18-month, prospective, descriptive study was conducted to identify and describe characteristics of intensive care unit (ICU) patients with skin failure and examine the relationships among patient demographics, nutritional status, laboratory parameters, the pres...

The shortage of organs for transplantation has led researchers to look for new techniques to expand the donor pool. Preconditioning strategies have the potential to protect organs from transplant associated injury or may improve the function of substandard organs so that they become suitable for transplantation. Translating this type of technology to the clinical setting raises ethical issues, ...

The development of systemic inflammation, acute lung injury, and multiple organ failure after a major thermal injury, as well as nonthermal forms of trauma, remain relatively common causes of morbidity and mortality. During the past two decades, increasing recognition that the ischemic gut may contribute to the development of sepsis and organ failure in burn patients, as well as other criticall...

severe intraabdominal infection associated with abdominal wall, intraperitoneal and remote organ complications, still carries an unacceptably high morality rate. in addition to the fundamental principle of eradication of the source of infection, various treatment modalities have been suggested to improve the commonly grave outcome. amongst these, open management (om) of the septic abdomen, even...

Multiple organ failure (MOFE) in elderly patients is a new clinical syndrome different from multiple organ failure (MOF) caused by surgical conditions in the young and middle-aged persons. One thousand and two cases of MOFE were analyzed retrospectively and their clinical features discussed. MOFE has a long insidious course. Its main predisposing factors are pulmonary infection, heart attack, e...