BACKGROUND To examine the effect of in utero exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) on age at menarche in offspring, we conducted a cohort study over two generations. METHODS Female participants (and their offspring) in a Michigan angler cohort in which organochlorine levels had been determined previously were studied. Of their 213 female offsp...

This paper overviews the contamination caused by persistent organochlorines in endocrine system of mammals. To overcome yield loss in crops plants via pests, it is necessary to control them. There are a number of pest control strategies. But in developing and under developed countries, most of the farmers are using pesticides without a proper way and proper knowledge. Out of total applied pesti...

Most humans have detectable body burdens of polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), and p,p'-dichlorophenyldichloroethylene p,p'-DDE), a metabolite of p,p'-dichlorodiphenyltrichloroethane (DDT). Native American communities may be at increased risk of exposure through subsistence-based diets and greater physical contact with contaminated soil and water. In this article we desc...

Tomato (Lycopersicum esculentum) is prominent among vegetables produced in Ghana. About ninety percent (90%) of the population of the study area are engaged primarily in tomato production. Due to the problem posed by pests and diseases and the vulnerability of vegetables to most of these pests and diseases, a variety of pesticides including organophosphates, Organochlorines, carbamates, and syn...

Organochlorine compounds have been demonstrated to have detrimental health effects in both wildlife and humans, an effect largely attributed to their ability to mimic the hormone estrogen. Our laboratory has studied cell signaling by environmental chemicals associated with the estrogen receptor (ER) and more recently via ER-independent mechanisms. Here, we show that the organochlorine pesticide...

Retinoids, also known as vitamin A, are non-endogenous molecules that essential for a number of physiological processes in mammals. Imbalance retinoids has been associated with reproductive impairment, embryonic mortality, growth retardation and bone deformities, pathologies skin the nervous system, immune suppression. Mammals cannot produce so their primary source is dietary. They absorbed by ...