The present investigation deals with histopathological and histochemical studies of profenophos on liver and kidney of male albino rats and the protective effects of vitamin C and ginseng to reduce the deleterious effect induced by profenophos. Oral administration of profenophos at dose level of 1 /10 LD50 for 15 successive days induced histological changes in liver and kidney. No histological ...

In this study, the efficiency of a clean-up method by gel permeation chromatography (GPC) for the separation of pesticides from lanolin is analyzed. The pesticides analyzed belong to two different families, organophosphorous and synthetic pyrethroids. Lanolin, a standard mixture of the pesticides, and a lanolin-pesticides mixture are injected in a GPC column. The recoveries and elution times fr...

Organophosphorous compounds cause fatal intoxication based on inhibition of acetylcholinesterase, an essential enzyme of neurosynapses and neuromuscular junctions. There is an obvious need to develop appropriate treatment against them due to their application in agriculture and chemical industry or their misuse in terrorist or war attack. In the Czech army some medicaments have been established...

Heavy metals, various pesticide and herbicides are implicated as risk factors for human health. Paraquat, maneb, and rotenone, carbamate, and organophosphorous insecticides are examples of toxicants for which acute and chronic exposure are associated with multiple neurological disorders including Parkinson's disease. Nevertheless, the role of pesticide exposure in neurodegenerative diseases is ...

Three-dimensional microscale assemblies of fluorine-doped titania nanoparticles were synthesized from silica-based diatom microshells (frustules) via a shape-preserving reactive conversion process (as per the method of Unocic et al.). The nanostructured F-doped titania frustules were found to induce rapid hydrolysis of the organophosphorous esters, methyl paraoxon, and methyl parathion (insecti...

To elucidate the role of acetylcholinesterase (AChE) enzyme in BBB function, phosalone, an organophosphorous compound, was studied using rat brain micro vessels in vitro. Phosalone at 100 mg/kg b. wt. induced convulsions and caused a significant inhibition of AChE resulting in increased permeability as assessed by volume distribution. The anaesthetized phosalone treated group also increased per...

Attempted suicide due to overdose with toxic chemicals and medication is on the rise. Among the survivors of attempted suicide, the most frequent psychiatric diagnosis when analysed post hoc, seems to be reactive depression and personality disorders. We conducted a retrospective study of patients who attempted suicide by self poisoning in a teaching general hospital. The most frequent LCD. 10 p...