نتایج جستجو برای: orthomyxoviridae
تعداد نتایج: 8630 فیلتر نتایج به سال:
Tick-borne Thogoto virus (THOV) represents the prototype virus of a new genus in the Orthomyxoviridae family. Its genome consists of six segments of negative-sense, single-stranded RNA. We have cloned and sequenced the fifth genomic segment, which codes for the viral nucleoprotein (NP). The deduced amino acid sequence shows 43% similarity to the NP of Dhori virus, a related tick-transmitted ort...
The early host response to pathogens is mediated by several distinct pattern recognition receptors. Cytoplasmic RNA helicases including RIG-I and MDA5 have been shown to respond to viral RNA by inducing interferon (IFN) production. Previous in vitro studies have demonstrated a direct role for MDA5 in the response to members of the Picornaviridae, Flaviviridae and Caliciviridae virus families ((...
The genome of infectious salmon anemia virus (ISAV), which infects farmed Atlantic salmon (Salmo salar L.), is characterized here. The virus has an RNA genome, as shown by using specific DNA virus metabolic inhibitors and radioactive in vivo labeling of ISAV nucleic acid. Electrophoresis of [14C]uridine-labeled ISAV RNA revealed that the ISAV genome is segmented. The genome consists of eight se...
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. Human pathogens in the Orthomyxovirida...
Influenza viruses belong to the family Orthomyxoviridae of enveloped viruses and are an important cause of respiratory infections worldwide. The influenza virus is able to infect a wide variety species as diverse as poultry, marine, pigs, horses, and humans. Upon infection with influenza virus the innate immunity plays a critical role in efficient and rapid control of viral infections as well a...
I N T R O D U C T I O N Avian influenza (AI) (Orthomyxoviridae) is a well-known viral disease that affects birds worldwide. In recent years, highly pathogenic avian influenza (HPAI) has re-emerged worldwide, raising concern in human and veterinary health authorities. Avian influenza has been reported in many countries from the Middle East region. In Pakistan outbreaks of HPAI H7N3 subtype occur...
Influenza A and B viruses belong to the Orthomyxoviridae family of viruses. These viruses are responsible for severe morbidity and significant excess mortality each year. Infection with influenza viruses usually leads to respiratory involvement and can result in pneumonia and secondary bacterial infections. Vaccine approaches to the prophylaxis of influenza virus infections have been problemati...
Description: With more than 100 million birds either dead from infection or culled, the present outbreak of avian influenza in Asia is unprecedented in size. Influenza virus belongs to the viral family, Orthomyxoviridae having single-stranded RNA genome in an enveloped virion. These viral particles are pleiomorphic and many of them are spherical or ovoid with 80-120 nm diameter. However, other ...
Avian influenza (AI) viruses are Type A influenza viruses of the Orthomyxoviridae family. There are 15 subtypes of the virus widespread in migratory waterfowl throughout the world. It has become increasingly evident that some low pathogenic avian influenza (LPAI) H5 or H7 viruses have the capacity to mutate into the more virulent strains that cause extensive economic losses and high mortality. ...
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