Growth factors have represented an essential issue of interest for the researchers and clinicians in orthopedics and trauma over the last 40 years. In the last 10 to 15 years, the advances registered in this field have permitted the identification of the most active cellular and humoral factors as well as the improvement of their use in the orthopedic and trauma surgery. Their domain of applica...

The current thesis originates from research efforts in the oncology and orthopedic departments at Lund University Hospital, and treats what initially appeared to be two different subjects. One subject deals with the epidemiology of adult soft tissue sarcomas (STS), a group of often fatal diseases of unknown cause, treated by both oncologists and orthopedic surgeons. Here, the historical inabili...

The goals of this study were to: (1) define the publication productivity of early-career orthopedic trauma surgeons over time; (2) compare the early-career publication productivity of recent orthopedic trauma fellowship graduates vs their more senior colleagues; and (3) determine the proportion of fellowship graduates who meet the Orthopaedic Trauma Association (OTA) publication criteria for ac...

BACKGROUND High post-operative pain scores after "minor" orthopedic/trauma surgery are in part attributed to inadequate prescription of opioid analgesics. Novel concepts aiming to achieve sufficient analgesia while minimizing opioid-related side effects by avoiding fluctuating plasma levels are based on perioperative oral administration of extended-release opioids beginning with the first dose ...

A high rate of patients lost to follow-up is a common problem in orthopedic trauma surgery. This adversely affects the ability to produce accurate clinical outcomes research. The purpose of this project was to (1) evaluate the rate of loss to follow-up at an academic level I trauma center; (2) identify the patient-reported reasons for loss to follow-up; and (3) evaluate the efficacy of a routin...

ABSTRACT Introduction Orthopedic trauma is a significant portion of global burden disease in low- and middle-income countries (LMICs). This has led the World Health Organization to advocate for increased surgical intervention LMICs. The two largest barriers orthopedic care LMICs are cost procedure geographic access centers with appropriate capabilities. There no current consensus on how structu...

BACKGROUND: Standard anesthesia monitoring during surgery only indirectly allows us to estimate achieving an effective level of analgesia sufficient protect the patient from surgical trauma. Recently, studies have analyzed cortisol, glucose, and lactate levels in children adults; however, data presented remain inconsistent.
 OBJECTIVE: This study aimed conduct a prospective comparative ana...

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1Division Space Physiology, Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany; 2Institute of Biomechanics and Orthopaedics, German Sport University Cologne, Cologne, Germany; 3Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, China; 4Department of Orthopedic and Trauma Surgery, University of Col...