BACKGROUND F18-fluorodeoxyglucose positron-emission tomography (FDG-PET) reconstruction algorithms can have substantial influence on quantitative image data used, e.g., for therapy planning or monitoring in oncology. We analyzed radial activity concentration profiles of differently reconstructed FDG-PET images to determine the influence of varying signal-to-background ratios (SBRs) on the respe...

BACKGROUND: Positron emission tomography (PET) is a powerful imaging technique with the potential of obtaining functional or biochemical information by measuring distribution and kinetics of radiolabelled molecules in a biological system, both in vitro and in vivo. PET images can be used directly or after kinetic modelling to extract quantitative values of a desired physiological, biochemical o...

UNLABELLED The aim of this study was to compare the performance of filtered backprojection (FBP) and ordered-subset expectation maximization (OSEM) reconstruction algorithms available in several types of commercial SPECT software. METHODS Numeric simulations of SPECT acquisitions of 2 phantoms were used: the National Electrical Manufacturers Association line phantom used for the assessment of...

BACKGROUND The clinical validation of the EARL harmonization program for standardised uptake value (SUV) metrics is well documented; however, its potential for defining metabolic active tumour volume (MATV) has not yet been investigated. We aimed to compare delineation of MATV on images reconstructed using conventional ordered subset expectation maximisation (OSEM) with those reconstructed usin...

Iterative reconstructions for clinical PET must run fast. We describe a clinical processing method based on sinogram rebinning, Fourier rebinning for the 3D to 2D data reduction, and iterative reconstruction using the attenuation-weighted OSEM method with a projector based on a gaussian pixel model. When this approach is used, multi-bed clinical oncology scans can be ready for diagnosis within ...

In dynamic PET studies, the changing activity of the radiotracer is measured through multiple consecutive time frames. Subsequently, the radioactivity distribution for each frame is obtained by a method known as reconstruction. Then, the distribution of the physiological parameter of interest is estimated by applying an appropriate pharmacokinetic model. Thus, the kinetic parameters are obtaine...

OBJECTIVES In order to evaluate the effect of post-reconstruction Gaussian filtering on image quality and myocardial blood flow (MBF) measurement by dynamic N-13 ammonia positron emission tomography (PET), we compared various reconstruction and filtering methods with image characteristics. METHODS Dynamic PET images of three patients with coronary artery disease (male-female ratio of 2:1; age...