The resistance of Candida albicans to many stresses is dependent on the stress-activated protein kinase (SAPK) Hog1. Hence we have explored the role of Hog1 in the regulation of transcriptional responses to stress. DNA microarrays were used to characterize the global transcriptional responses of HOG1 and hog1 cells to three stress conditions that activate the Hog1 SAPK: osmotic stress, oxidativ...

Recent pharmaceutical research has focused on controlled drug delivery having an advantage over conventional methods. Adequate controlled plasma drug levels, reduced side effects as well as improved patient compliance are some of the benefits that these systems may offer. Controlled delivery systems that can provide zero-order drug delivery have the potential for maximizing efficacy while minim...

Abstract A 191, a Neo-Assyrian tablet from the Haus des Beschwörungspriesters in Aššur, preserves instructions for performance of an apotropaic ritual called Bīt mēseri (“house enclosure”). The tablet, which is edited here first time, offers version ceremony that markedly different standard known other first-millennium sources found at Nineveh, and various Babylonian sites. Whereas core rites w...

PURPOSE The available scientific research regarding injury prevention practices in international football is sparse. The purpose of this study was to quantify current practice with regard to (1) injury prevention of top-level footballers competing in an international tournament, and (2) determine the main challenges and issues faced by practitioners in these national teams. METHODS A survey w...

The aim was to assess the bioequivalence of Sandoz methylphenidate osmotic-controlled release (OCR) tablets (Sandoz [Methylphenidate[ MPH OCR) with Concerta®, a methylphenidate formulation indicated for the treatment of attention deficit/hyperactivity disorder (ADHD). Four open-label, randomized, single-dose, two-way crossover bioequivalence studies were conducted in healthy subjects: three fas...

Pipeline inspection gauges (PIGs), as a kind of pipeline robot, are very efficient tools for cleaning and inspecting pipelines. However, the occurrence obstructions in PIGs has always been problem. The main cause PIG clogging problem is reduced pressure differential between front rear due to damage cup. In this paper, rigid-flexible coupled multibody dynamic motion system established by importi...

In majority of individuals blood pressure rises in the early morning hours, which lead to serious cardiovascular complications. Formulation of pulsatile system makes it possible to deliver drug at definite period of time when symptoms of the disease condition are most critical. The purpose of the present work was to develop pulsatile release tablet of losartan potassium for chronotherapy in hyp...

Cilnidipine, a novel calcium antagonist accompanied with Ltype and N-type calcium channel blocking function, is mainly used for treatment of hypertension. Due to its N-type calcium channel blocking properties, it has more advantages compared to conventional calcium channel blockers. The present investigation is aimed to formulate a pulsatile drug delivery system with a lag time of about 6 hr. C...

Paradoxical effects (bronchoconstriction instead of bronchodilatation) have been reported after inhalation of beta2-mimetics in asthmatic children, and it has been suggested that this was due to osmolality and pH changes of the nebulizer solution. We tested commercially available nebulizer solutions and found osmolality changes after 5, 10 and 15 min of nebulization. Osmolality was measured in ...