I T HAS been demonstrated by Fahraeus’4 that normal red blood cells have a tendency to bcccme spheroidal in shape after standing in vitro at body ternperature. G#{228}nsslen,5 Haden6 and Castle and Daland7 have shown that spheroidal red cells are more susceptible to osmotic hemolysis than are normal corpuscles. Haden found that normal red cells when suspended in graded hypotonic salt solutions ...

Serum bilirubin was in the range 2 to 5 mg/dL. Osmotic fragility showed mild increase in fragility (Test 0.5-0.28: Control 0.44-0.34). Hb electrophoresis was normal. HbF was <2%, G6PD enzyme level was normal. Direct Coomb’s test and sickling test were negative. HBSAg and HCV and ANA were negative. USG abdomen showed splenohepatomegaly. The pedigree showed that the mother’s uncle also had simila...

This study was designed to test the hypothesis that supplementation with vitamin E, an antioxidant, in cats with chronic kidney disease (CKD), would reduce oxidative stress and its impact on RBC membrane fragility, resulting in these cats maintaining a greater packed cell volume (PCV) compared with CKD cats not receiving supplementation. Thirty-six cats with CKD were randomly assigned to receiv...

* Corresponding author. e-mail: [email protected] or [email protected]. The effect of prolonged use of Iodosteryl, a polyvalent iodophorous compound, as water disinfectant, on the hematology and erythrocyte osmotic fragility of the domestic chicken was investigated. Twenty eight adult male domestic chickens of the Nera black strain were divided into four groups of seven birds p...

Both mitochondrial ATP-sensitive K+(KATP) channels and the actin cytoskeleton have been proposed to be end-effectors in ischemic preconditioning (PC). For evaluation of the participation of these proposed end effectors, rabbits underwent 30 min of regional ischemia and 3 h of reperfusion. PC by 5-min ischemia + 10-min reperfusion reduced infarct size by 60%. Diazoxide, a mitochondrial KATP-chan...