A scaffold for bone tissue engineering should have highly interconnected porous structure, appropriate mechanical and biological properties. In this work, we fabricated well-interconnected porous β-tricalcium phosphate (β-TCP) scaffolds via selective laser sintering (SLS). We found that the mechanical and biological properties of the scaffolds were improved by doping of zinc oxide (ZnO). Our da...

Calcium phosphate ceramics are widely used as bone substitutes in dentistry and orthopedic applications. For minimally invasive surgery an injectable calcium phosphate ceramic suspension (ICPCS) was developed. It consists in a biopolymer (hydroxypropylmethylcellulose: HPMC) as matrix and bioactive calcium phosphate ceramics (biphasic calcium phosphate: BCP) as fillers. The stability of the susp...

INTRODUCTION Bone grafting is an integral part of orthopaedic surgery; the use of bone graft is increasing consistently in traumatology and also in complex revision surgeries of hip and knee arthroplasties. Considering this fact there is a need for some way to find solution for a bone graft which has more osteoinduction, osteoconduction as well as osteogenecity and also reduced rates of graft r...

Background: Socket preservation using bone graft is one way to minimise resorption and maximise the formation process. Tumor necrosis factor-α (TNF-α) an inflammatory cytokine that affects regenerating osteoblast activity, while osterix (Osx) osteoblast-specific transcription factor activates gene receptors during pre-osteoblast differentiation. The hydroxyapatite (HA) scaffold from crab shells...

Background: Tooth extraction is surgical treatment with clinical manifestation alveolar bone resorption of 11-63% which potentially fails dental implant treatment. Socket preservation regeneration to minimize morphological changes in post-extraction using graft. Anti-inflammatory biomaterial needed modulate inflammatory cascade the lesion. Anthocyanin ternatin a flavonoid derived from butterfly...

Calcium phosphate salts, or more specifically hydroxyapatite, are products of great interest in the fields of medical and dental science due to their biocompatibility and osteoconduction property. Deproteinized xenografts are primarily constituted of natural apatites, sintered or not. Variations in the industrial process may affect physicochemical properties and, therefore, the biological outco...

The purpose of this study was to investigate the effect of new bone substitute materials consisting of collagen and tricalcium phosphate (TCP). Prior to the experiment, mandibular dog teeth were extracted. After 3 months, specific cavities were prepared on the alveolar ridge. In one group, cavities were filled with collagen sponge (CS group), in the other, cavities were filled with TCP sponge (...

Developing a successful bone tissue engineering strategy entails translation of experimental findings to clinical needs. A major leap forward toward this goal is developing a quantitative tool to predict spatial and temporal bone formation in scaffold. We hypothesized that bone formation in scaffold follows diffusion phenomenon. Subsequently, we developed an analytical formulation for bone form...

Our previous study revealed that mesoporous Ca-Si-based materials exhibited excellent osteoconduction because dissolved ions could form a layer of hydroxycarbonate apatite on the surface of the materials. However, the biological mechanisms underlying bone regeneration were largely unknown. The main aim of this study was to evaluate the osteogenic ability of large-pore mesoporous Ca-Si-based bio...

This study used synchrotron X-ray microtomography on a micron scale to compare three-dimensional (3D) bone ingrowth after implantation of various calcium phosphate bone substitutes in a rabbit model. The advantage of using this new method for the study of biomaterials was then compared with histomorphometry for analysis of interconnection and bone ingrowth. The study focused on the newly formed...