The use of otoacoustic emissions to predict ototoxic-induced hearing changes" (2009). Scholar Archive. Paper 483.

Uniform drug delivery techniques are challenging to develop for the inner ear due complexity of cochlear anatomy. A promising solution is use biodegradable polymers because continuous release therapeutics without introducing toxic compounds desirable. Using a microneedle approach lends polymeric capability be placed inside scala tympani, releasing drugs overtime. Poly(lactic-co-glycolic acid) (...

The ear is a complex structure consisting of the outer, middle and inner ear. For proper function auditory system, development all these parts needs to be highly organized. Any alterations in this chain events can lead hearing loss or other impairments, such as dizziness, tinnitus balance. Of note, several external internal elements, including noise exposure, ototoxic drugs, aging, well environ...

Transient evoked otoacoustic emissions (TEOAEs) have been analyzed for objective assessment of hearing function and monitoring of the influence of noise exposure and ototoxic drugs. This paper presents a novel application of the Hilbert–Huang transform (HHT) for detection and time-frequency mapping of TEOAEs. Since the HHT does not distinguish between signal and noise, it is combined with ensem...

Evidence is presented to support the hypothesis that the cochleae of young animals are more susceptible to auditory trauma than the cochleae of the adult. A sensitive period of heightened susceptibility to acoustic trauma from noise exposure has been demonstrated in three mammalian species. The cochlear pathology associated with this trauma is severe damage to the outer hair cell system. Abnorm...

Introduction: Hidden hearing loss (HHL) is a type of auditory disorder that affects the neural processing and sensitivity in subjects with normal thresholds. Unlike central disorders, HHL happens when cochlea (the peripheral organ) affected. There are several known risk factors to which includes noise exposure, ototoxic drugs, neuropathies, age. Recent studies have shed light on this loss, its ...