Cows' milk contains considerable quantities of estrogens, mainly in the form of estrone sulfate (ES). To determine whether the commercial milk has any biologically significant hormonal effects, 2 series of uterotrophic tests were performed, 1 with young ovariectomized rats and the other with sexually immature rats. Thirty-six rats were used for each test. They were divided into 3 groups of 12 a...

Blackberry leaves (Morus nigra) are used in menopause to relieve hot flashes and night sweats have been investigated metabolic disorders. However, few studies its effects on behavioral disorders when associated with menopause. This study evaluated the of a hydroalcoholic extract M. nigra (MN) body composition, glucose tolerance, depression anxiety-like behaviors ovariectomized rats. For this pu...

Retinol is a commonly used vitamin, especially by elderly people. Alendronate sodium, an aminobisphosphonate, is a potent antiresorptive drug used in the treatment of osteoporosis in postmenopausal women. Frequently, alendronate sodium and retinol are used concurrently. There are no reports on the interaction between alendronate sodium and retinol. The aim of the present study was to investigat...

The purpose of this study was to compare the effects of aerobic, resistance, or combined exercise training on cardiovascular autonomic control and mortality in diabetic ovariectomized rats. Female Wistar rats were divided into one of five groups: euglycemic sedentary (ES), diabetic ovariectomized sedentary (DOS), diabetic ovariectomized aerobic-trained (DOTA), diabetic ovariectomized resistance...

Licorice is a medicinal plant showing many therapeutic activities. Its roots contain numerous pharmacologically active compounds such as a triterpenoid saponin--glycyrrhizic acid and an isoflavan--glabridin. There are reports indicating that glabridin exhibits estrogen-like activity, therefore it can be classified into phytoestrogens, which may soothe menopause symptoms including postmenopausal...

BACKGROUND Loss of bone quality and deterioration of articular cartilage are commonly seen after menopause. While exercise may protect against tissue degeneration, a clear link has yet to be established. The aim of the present study is to investigate the influence of long-term treadmill exercise on changes in bone mass and articular cartilage in ovariectomized rats. METHODS Sixty female Sprag...

Tamoxifen is widely used in breast cancer therapy and in the treatment of all stages of breast cancer including chemoprevention in women at high risk of the disease. The most important aspect of tamoxifen therapy concerns its influence on bone tissue and lipid metabolism. The aim of the study was to evaluate the effect of tamoxifen on bone metabolism and blood cholesterol levels in ovariectomiz...

Objective- This study was designed to determine the effect of pomegranate seed oil (PSO) treatment on oxidative stress and lipid profiles in ovariectomized (OVX) rats. Design- Experimental study Animals- 24 female Wistar rats Procedures-The rats were randomly divided into four groups: sham-operated (SHAM), SHAM with PSO treatment (SHAM + PSO), ovariectomized (OVX), and ovariectomized with PSO t...

OBJECTIVE Osteoporosis increases the risk of bone fractures and may impair fracture healing. The aim of this study was to investigate whether alpha-tocopherol can improve the late-phase fracture healing of osteoporotic bones in ovariectomized rats. METHOD In total, 24 female Sprague-Dawley rats were divided into three groups. The first group was sham-operated, and the other two groups were ov...