17 Obstructive sleep apnea (OSA) is one of the most common causes of hypertension 18 in western societies. OSA causes chronic intermittent hypoxia (CIH) in specialized O 2-19 sensing glomus cells of the carotid body. CIH generates increased reactive oxygen 20 species (ROS) that trigger a feed-forward mechanism in which increased intracellular 21 calcium levels ([Ca 2+ ] i) trigger increased HIF...

Oxidative stress accompanies a wide spectrum of clinically important cardiac disorders, including ischemia/reperfusion, diabetes mellitus, and hypertensive heart disease. Although reactive oxygen species (ROS) can activate signaling pathways that contribute to ischemic preconditioning and cardioprotection, high levels of ROS induce structural modifications of the sarcomere that impact on pump f...

It has long been recognized that energy metabolism is linked to the production of reactive oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by redox reactions. This interplay between energy metabolism and ROS becomes most apparent during the aging process and in the onset and progression of many age-related diseases (i.e. diabetes, metabolic syndrome, ather...

Leakage of mitochondrial oxidants contributes to a variety of harmful conditions ranging from neurodegenerative diseases to cellular senescence. We describe here, however, a physiological and heretofore unrecognized role for mitochondrial oxidant release. Mitochondrial metabolism of pyruvate is demonstrated to activate the c-Jun N-terminal kinase (JNK). This metabolite-induced rise in cytosolic...

Cervical cancer shows a high prevalence among Bangladeshi women. Reports indicated that oxidant-antioxidant balance plays role in cervical pathogenesis. Therefore, this study explores the change of different blood-derived enzymes, antioxidants, and biomarkers to understand oxidative stress status patients. A clinician recruited case control participants for based on histopathologic reports. No ...

The abnormal adherence of sickle red blood cells (SS RBC) to endothelial cells has been thought to contribute to vascular occlusion, a major cause of morbidity in sickle cell disease (SCD). We determined whether the interaction of SS RBC with cultured endothelial cells induced cellular oxidant stress that would culminate in expression of cell adhesion molecules (CAMs) involved in the adhesion a...

background: imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including oral cancer. majority of oral cancer are preceded by a well-recognized group of pre-malignant lesions. however, only a small fraction of those lesions, undergo malignant transformation. hence, there is a great need to identify biological markers, which will assis...

Increased salt intake attenuates the endothelium-dependent dilation of skeletal muscle arterioles by abolishing local nitric oxide (NO) activity. There is evidence of oxidative stress in arteriolar and venular walls of rats fed a high-salt diet, and depressed arteriolar responses to acetylcholine (ACh) in these rats are reversed by scavengers of reactive oxygen species (ROS). In this study, we ...