Chromosomal DNA and mitochondrial dysfunctions play a role on mammalian cell death induced by oxidative stress. The major biochemical dysfunction of chromosome is the presence of an ordered cleavage of the DNA backborn, which is separated and visualized as an electrophoretic pattern of fragments. Oxidative stress provides chromatin dysfunction such as single strand and double strand DNA fragmen...

BACKGROUND Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS) originate mainly from endogenous sources, namely the mitochondria. METHODOLOGY/PRINCIPAL FINDINGS We analyzed the effect of aerobic metabolism on oxidative damage in Schizosaccharomyces pombe by global mapping of those genes that are required for growth on both respiratory-proficien...

Dysregulated production of reactive oxygen species (ROS) during oxidative stress has been associated with a number of inflammatory and age-related degenerative diseases. ROS can directly react with DNA to form oxidized DNA bases. Direct protein oxidation and carbonylation occur on certain amino acid residues resulting in various post-translational modifications. ROS can also initiate the format...

Major depression is known to be associated with cardiovascular abnormalities, and oxidative stress has been suggested to play a role. We tested the hypothesis that antidepressant treatment reduces oxidative stress and endothelial dysfunctions in the chronic mild stress (CMS) model of depression in rats. Rats with >30% reduction in sucrose intake after 4 wk of CMS were defined in the study as CM...

BACKGROUND Metabolic syndrome is characterized by the association of 3 or more risk factors, including: abdominal obesity associated with an excess of abdominal fat, insulin resistance, type 2 diabetes, dyslipidemia and hypertension. Moreover, the prevalence of hypertension and metabolic dysfunctions sharply increases after the menopause. However, the mechanisms involved in these changes are no...

BACKGROUND Obstructive sleep apnea is characterized by repetitive pharyngeal collapses during sleep, leading to intermittent hypoxia (IH), the main contributor of obstructive sleep apnea-related cardiovascular morbidity. In patients and rodents with obstructive sleep apnea exposed to IH, vascular inflammation and remodeling, endothelial dysfunction, and circulating inflammatory markers are link...

OBJECTIVES To determine the frequency of temporomandibular disorders (TMDs) and investigate their relationship with sleep quality in 18 and 19-year-old adolescents. METHODS Cross-sectional design; dysfunctions were diagnosed using the Research Diagnostic Criteria for Temporomandibular Disorders and sleep was assessed using the Pittsburgh Sleep Quality Index in 200 students. Data were analyzed...

Cognitive dysfunction (CD) is manifested as forgetfulness and memory loss, accompanied by language, mental, motor dysfunctions etc. Rhizoma Polygonati (RP) a traditional Chinese medicine for both medicinal edible uses in China, which have the functions of improving learning abilities, but neuroprotection on Mice with Dysfunction unclear. In present study, ability processed RP CD mice induced D-...

Purpose: To investigate the neuroprotective effect of natural flavonoid rhoifolin in rats with streptozotocin (STZ)-induced (AD).
 Methods: Morris water-maze and novel object recognition tests were carried out to estimate on memory cognition. Histopathological analysis was made observe thickness hippocampal CA1 pyramidal layer. Analysis oxidative stress markers performed hippocampus fronta...

BACKGROUND Myocardial depression in sepsis is common, and it is associated with higher mortality. In recent years, the hypothesis that the myocardial dysfunction during sepsis could be mediated by ischemia related to decreased coronary blood flow waned and a complex mechanism was invoked to explain cardiac dysfunction in sepsis. Oxidative stress unbalance is thought to play a critical role in t...