Background and Aims:In neurodegenerative disorders,oxidative stress mediated by reactive oxygen species is strongly associated with increased neuronal damages which can lead to apoptosis. Pro-apoptotic and anti-apoptotic gene expressions are changed during the cell differentiation that affect cell viability and differentiation. Therefore, this study was conducted to determine the effects of hyd...

objective: oxidative stress is involved in the pathophysiology of diabetes and cardiovascular complications of metabolic syndrome. the main objective of this study was to evaluate total antioxidant status by diphenylpicrylhydrazyl (dpph)-scavenging activity in patients developed metabolic syndrome (mets). materials and methods: forty-four patients with mets diagnosed on the basis of adult treat...

results the level of gsh significantly decreased. in contrast, the plasma level of mda significantly increased in a dose dependent manner in crvi-treated rats, when compared to control animals. simv had no effect on the biochemical parameters when compared to control rats, but significantly increased gsh concentration and decreased mda level in crvi-treated rats. materials and methods sixty-fou...

introduction: toxic effects of pesticides are commonly associated with reactive oxygen species damage and pentoxifylline a phosphodiesterase inhibitor is a drug well known for antioxidant properties. the purpose of this study was to evaluate the oxidative damages following a subacute exposure to malathion, an organophosphorus insecticide and pentoxifylline's ability to counteract these eff...

background: cyclosporine a (csa) is a potent immunosuppressant drug with therapeutic and toxic actions. the use of csa is limited by its toxicity. several researchers had proposed that oxidative stress could play an important role in csa-induced toxicity. arbutin has recently been shown to possess antioxidative and free radical scavenging abilities.the present study was designed to investigate ...

introduction: nowadays, spermatogonial stem cells (sscs) cultivation has been used by many researchers as an effective tool for infertility treatments. oxidative conditions can be effective on cell proliferation and differentiation of these cells. so, the aim of this study was to establish oxidative stress model for antioxidant activity of some drugs investigation during sscs in vitro culture. ...

doxorubicin (dox) is an anthracycline antibiotic that has been used for a long time in therapy of an array of human malignancies either alone or in combination with other cytotoxic agents. the dose-dependent cardiotoxicity of dox significantly limits its anticancer efficacies. oxidative stress caused by enhanced production of reactive oxygen species is an important contributor to dox mitochondr...

osteoporosis is a disease of high prevalence with increased bone loss. it has potential public health threat and that the health authorities had taken several measures for its control. in recent years, considerable attention has been given to physiopathology of osteoporosis. oxidative stress has been proved to be involved in bone resorption. oxidative stress occurs when balance between oxidants...

the study aimed to investigate the protective effects of crocin (cro) against streptozotocin (stz)-induced oxidative damage in rat striatum. animals were randomly divided into four groups (five each). group 1 (sham) were treated with normal saline (2 ml/kg, p.o.). group 2 (stz-lesioned or lesion) were injected with icv-stz (3 mg/kg bilaterally, on day 1 and 3) and treated with normal saline (2 ...

background: hawthorn species decreases blood pressure and relaxes precontracted vessels. this study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension. methods: six groups of male sprague-dawley rats, each containing 6 to 8 rats, were studied. the groups comprised of...