BACKGROUND Elevated concentrations of homocysteine and low concentrations of folate may lead to a proinflammatory state that could explain their relation to vascular disease risk. We investigated the effect of lowering homocysteine concentrations by means of folic acid supplementation on markers of inflammation. METHODS In a double-blind, randomized, placebo-controlled trial among 530 men and...

background: oxidative modification of low-density lipoprotein (ldl) appears to be an early step in the pathogenesis of atherosclerosis. meanwhile, myeloperoxidase (mpo)-catalyzed reaction is one of the potent pathway for ldl oxidation in vivo. the aim of this study was to evaluate in vitro antioxidant effects of vitamins c and e on ldl oxidation mediated by mpo. methods: mpo was isolated from f...

BACKGROUND Psoriasis is a chronic inflammatory skin disease characterized by an accelerated turnover of epidermal cells and an incomplete differentiation in epidermis with lesion. However, the exact etiology of psoriasis is unknown. Abnormalities in essential fatty acid metabolism, free radical generation, lipid peroxidation, and release of lymphokines have been proposed. OBJECTIVE Our purpos...

4 5 6 7 Chongxu Zhang, Crystal Adamos, Myung-Jin Oh, Jugajyoti Baruah, Manuela A.A. Ayee, 8 Dolly Mehta, Kishore K. Wary, Irena Levitan 9 10 Division of Pulmonary and Critical Care, Department of Medicine and Department of 11 Pharmacology, University of Illinois at Chicago 12 13 14 Running Title: OxLDL and endothelial proliferation 15 16 17 18 19 20 21 Corresponding Author: 22 Irena Levitan 23 ...

Interaction of oxidized LDL (OxLDL) with macrophage-derived foam cells is one of the key events in the development and progression of atherosclerosis. To study this interaction, macrophage-derived foam cells were isolated from rabbit atherosclerotic lesions and the expression of scavenger receptors for OxLDL was examined. Atherosclerosis was induced in rabbits by denudation of the large arterie...

Fig 4 is incorrect. The correct Fig 4 is available here. access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

BACKGROUND Several studies suggest that C-reactive protein (CRP) is associated with coronary artery disease in adults. However, this association has not been thoroughly explored in cases of adolescents. OBJECTIVE To evaluate the association between CRP and cardiovascular risk factors in obese adolescents. METHODS Eighty-four adolescents (12.6 +/- 1.3 years) of both genders were divided into...

This image-object relationship has been evaluated in a radiographic study of ox femora. The soft tissues were removed from the proximal ends of 5 specimens and the bones were each cut in the medio-lateral plane into 5 slices. The image of the trabecular pattern on the radiograph of each slice was very different to that of the whole bone. These trabecular patterns are diagramatically represented...

OBJECTIVE Patients with chronic kidney disease (CKD) display impaired cholesterol efflux capacity and elevated CD14(++)CD16(+) monocyte counts. In mice, dysfunctional cholesterol efflux causes monocytosis. It is unknown whether cholesterol efflux capacity and monocyte subsets are associated in CKD. APPROACH AND RESULTS In 438 patients with CKD, mediators of cholesterol efflux capacity (high-d...

We have previously shown that CD36 recognizes oxidation products of phospholipids on oxidized LDL (OxLDL) such as 1-palmitoyl-2-(5'-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC). The current study was designed to examine whether the phosphocholine (PC) headgroup in POVPC constitutes an obligatory binding target for CD36. To examine the contribution of PC in the binding of POVPC to CD36, we u...