Fifty-five patients received total cardiopulmonary support with the disposable Lande-Edwards membrane oxygenator during aortocoronary artery-vein graft operations and other complex open heart operations. Two three meter2 membrane oxygenators were linked in parallel to a standard r o b pump apparatus. (Three 3 meter2 membranes for patients weighing 80 to 103 kg.) Excellent oxygen and carbon diox...

Based on the results of in vitro studies of many experimental models, a silicone hollow fiber membrane oxygenator for pediatric cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) was developed using an ultrathin silicone hollow fiber with a 300 microm outer diameter and a wall thickness of 50 microm. In this study, we evaluated the gas transfer performance of this oxyge...

Despite new minimally invasive techniques, cardiopulmonary bypass (CPB) is still necessary for many major operations in the field of cardiac surgery. Unwanted side effects of CPB are well known but poorly understood. We therefore developed a rodent model to study the pathophysiology of these potential complications. Male Fischer rats were anaesthetized, intubated and ventilated. The carotid art...

During the course of extracorporeal membrane oxygenation, patients are at constant risk of exposure to air emboli. Air emboli may enter the circuit during routine lab sampling, medication administration, air entrainment through the venous cannula, or via a circuit disruption. Circuit components have been designed and positioned to minimize the quantity of air that travels through the arterial l...

This study was carried out to determine whether an extracorporeal membrane oxygenation (ECMO) support could be sufficiently conducted by the right ventricle alone from the viewpoint of the hemodynamics and blood gas state. Six infant dogs underwent a bypass between the left pulmonary artery and left atrium with an in-line oxygenator after a left pneumonectomy. Partial ECMO support was conducted...

UNLABELLED Platelet adhesion on the cardiopulmonary bypass oxygenator membrane is associated with impaired hemostasis. We investigated the effects of heparin coating of the oxygenator membrane on protein adsorption and platelet adhesion on the surface. Noncoated and heparin-coated polypropylene membranes were incubated in whole blood with small- (1 U/mL) or large-dose (5 U/mL) heparin as an ant...

OBJECTIVE To analyze the security and efficacy of a new membrane oxygenator, the so-called OXM - 1500. METHODS From May 2005 to September 2006, six sheep of Santa Inês breed (five male and one female, respectively) were studied. The average body weight was 14.1 (+/-5) kg, body surface 0.6 (+/-0.2) m(2) and a mean age 3.8 (+/-1.5) months. All of them were submitted to extracorporeal circulatio...

The transition from bubble oxygenators to microporous membrane oxygenators is a good example of how industry working with customers and material suppliers can help improve a surgical technique, such as cardiopulmonary bypass. The development is characterized by many individuals who, through their inventiveness and determination, made the transition possible. While the medical personnel involved...