The aim of this study was to evaluate whether a short therapy cycle of oral methylprednisolone plus conventional therapy might improve isolated nocturnal hypoxemia evidenced through pulse-oxymetry in 28 patients (19 M/9 F; mean age 71 +/- 8.31) with stable moderate to severe COPD (average FEV1 of 43.33 +/- 9.38 of theoretical) and daytime PaO2 > 60 mmHg. All patients showed oxygen desaturation ...

BACKGROUND Kangaroo care (KC) has been widely using to improve the care of low birth weight infants. However, very little is known about cerebral hemodynamics responses in low birth weight infants during KC intervention. The objective of this study was to elucidate the response of cerebral hemodynamics during KC in low birth weight infants. METHODS Near infrared spectroscopy measured regional...

Background: The oxygen saturation of the central vein (ScVO2) has been regarded as a surrogate of tissue perfusion in patients of severe sepsis and major surgery. However, ScVO2 in acute coronary syndrome has not been addressed. We tried to delineate the trend of ScVO2 in patients of acute coronary syndrome. Methods and Patients: This was a prospective observational study in the coronary care u...

BACKGROUND Transcatheter aortic valve implantation (TAVI) is a treatment strategy for patients with severe aortic stenosis. Although general anaesthesia (TAVI-GA) and sedation (TAVI-S) have previously been described for TAVI, the difference in safety and efficacy of both methods has not been studied in a randomized trial. METHODS The INSERT trial was a single centre, controlled parallel-group...

OBJECTIVES To determine the incidence and pattern of various congenital heart disease in a neonatal unit of a tertiary care hospital. METHODS The prospective study was carried out in the neonatal unit of Combined Military Hospital, Rawalpindi, from September 2008 to August 2011. All 5800 neonates admitted with gestational age of > 28 weeks irrespective of birthweight were included in the stud...

Ischemia is one of the major factors causing secondary brain damage after severe head injury. We have investigated the value of continuous partial pressure of brain tissue oxygen (PbrO2) monitoring as a parameter for cerebral oxygenation in 22 patients with severe head injury (GCS ≤ 8). Jugular bulb oxygenation, intracranial pressure and cerebral perfusion pressure were simultaneously recorded....

Using the characteristics of T cell mitogen called lectin protein from the jack-beam Canavalia ensiformis Concanavalin A (Con_A) with dual activities, cytotoxicity and immunomodulation, we have shown it has a therapeutic effect on hepatoma. Injection of Con_A can eradicate the established malign tumor, because Con_A can induce tumor cell autophagic, cell-programmed death, as well as activate th...

abstract background: chest wall irradiation for early breast cancer affects forced vital capacity (fvc), forced expiratory volume in the first second of expiration (fev1) and may change peripheral oxygen saturation (spo2). in our institute chest wall is irradiated with a four field technique: two tangential and two oppositional anterior and posterior supraclavicular fields. regional recurrence ...

The shorter life expectancy of patients with type 2 diabetes caused by cardiovascular and cer-ebrovascular diseases compels clinicians to make a systematic effort to address traditional cardio-vascular risk factors, such as dyslipidemia, hypertension, hyperglycemia, obesity, and smoking. However, another major cardiovascular risk factor substantially influencing the quality and length of life –...