نتایج جستجو برای: p52
تعداد نتایج: 579 فیلتر نتایج به سال:
Introduction MEFV is the first identified autoinflammatory gene related to Familial Mediterranean Fever (FMF) disease. We previously the tested the hypothesize of epigenetic involvement in FMF, mainly based on the occurrence of FMF in patients without mutations and decreased MEFV transcripts in leukocyte samples independent from mutations. Our study showed that higher methylation level of MEFV ...
Influenza A virus (IAV) infection of epithelial cells activates NF-κB transcription factors via the canonical NF-κB signaling pathway, which modulates both the antiviral immune response and viral replication. Since almost nothing is known so far about a function of noncanonical NF-κB signaling after IAV infection, we tested infected cells for activation of p52 and RelB. We show that the viral N...
TNF-like weak inducer of apoptosis (TWEAK) receptor Fn14 is expressed by podocytes and Fn14 deficiency protects from experimental proteinuric kidney disease. However, the downstream effectors of TWEAK/Fn14 in podocytes are poorly characterized. We have explored TWEAK activation of non-canonical NFκB signaling in cultured podocytes. In cultured podocytes, TWEAK increased the expression of the ch...
An improved understanding of pathogenic pathways may identify novel acute kidney injury (AKI) therapeutic approaches. Unbiased LC-MS/MS protein expression profiling combined with focused data mining identified MAP3K14 and non-canonical NFκB activation at the crossroads of the enriched pathways MAPK, ubiquitin-mediated proteolysis, chemokines, NFκB and apoptosis in the kidney cortex of experimen...
TweakR is a TNF receptor family member, whose natural ligand is the multifunctional cytokine TWEAK. The growth inhibitory activity observed following TweakR stimulation in certain cancer cell lines and the overexpression of TweakR in many solid tumor types led to the development of enavatuzumab (PDL192), a humanized IgG1 monoclonal antibody to TweakR. The purpose of this study was to determine ...
This paper attempts to portray a synthesis of what has been learned in the past 10 years with regard to the transition process. It contrasts the mainstream “Washington consensus” view of transition with the “evolutionary institutionalist” perspective. It argues that the latter gives a more adequate and complete picture both of the transition processes and of economic systems and is of better he...
چکیده نرخ ارز واقعی، از جمله عواملی است که انحراف آن از مقادیر تعادلی و همچنین بی ثباتی در آن می تواند عملکرد اقتصاد کلان به ویژه رقابت پذیری کشورها را تحت تأثیر قرار دهد. نوسان های نرخ ارز واقعی نشان دهنده بی ثباتی وعدم قطعیت در روند قیمت های نسبی بین کشورهاست. این نوسان ها موجب ایجاد فضایی بی ثبات و نامطمئن در اقتصاد می گردند. از سویی دیگر فراهم نمودن فضای رقابتی و ارتقای سطح رقابت پذیری ملی...
Mutations in certain subunits of the DNA repair/transcription factor complex TFIIH are linked to the human syndromes xeroderma pigmentosum (XP), Cockayne's syndrome (CS), and trichothiodystrophy (TTD). One of these subunits, p8/TTDA, interacts with p52 and XPD and is important in maintaining TFIIH stability. Drosophila mutants in the p52 (Dmp52) subunit exhibit phenotypic defects similar to tho...
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