Fragile X syndrome (FXS), the most commonly inherited form of mental retardation and autism, is caused by transcriptional silencing of the fragile X mental retardation 1 (FMR1) gene and consequent loss of the fragile X mental retardation protein. Despite growing evidence suggesting a role of specific receptors and biochemical pathways in FXS pathogenesis, an effective therapeutic method has not...

We reported previously that Muc1 mucin on the epithelial cell surface is an adhesion site for Pseudomonas aeruginosa (Lillehoj EP, Hyun SW, Kim BT, Zhang XG, Lee DI, Rowland S, and Kim KC. Am J Physiol Lung Cell Mol Physiol 280: L181-L187, 2001). The present study was designed to identify the adhesin(s) responsible for bacterial binding to Muc1 mucin using genetic and biochemical approaches. Ch...

BACKGROUND The adaptor protein Nck consists of three Src homology 3 (SH3) domains followed by one SH2 domain. Like the Grb2 adaptor protein, which is known to couple receptor tyrosine kinases to the small GTPase Ras, Nck is presumed to bind to tyrosine-phosphorylated proteins using its SH2 domain and to downstream effector proteins using its SH3 domain. Little is known, however, about the speci...

MADS-box genes form a large gene family in plants and are involved in multiple biological processes, such as flowering. However, the regulation mechanism of MADS-box genes in flowering remains unresolved, especially under short-term cold conditions. In the present study, we isolated BcMAF1, a Pak-choi (Brassica rapa ssp. Chinensis) MADS AFFECTING FLOWERING (MAF), as a floral repressor and funct...

adresa za dopisivanje Prof. Francesco Carinci, MD Chair of Maxillofacial Surgery Arcispedale S. Anna Corso Giovecca 203 44100 Ferrara ITALY Phone/Fax: +39.0532.455582 [email protected] www.carinci.org Sažetak Svrha: Kako se povećava broj pacijenata s parodontnom bolešću koji se podvrgavaju ortodontskom liječenju (OL-u), a nema izvještaja specifično fokusiranog na utjecaj OL-a u slučaju pregradnje al...

We present a security reduction for the PAK protocol instantiated over Gap Diffie-Hellman Groups that is tighter than previously known reductions. We discuss the implications of our results for concrete security. Our proof is the first to show that the PAK protocol can provide meaningful security guarantees for values of the parameters typical in today’s world.

In this short note we give a simple geometric proof of the Collapsing Walls Lemma given by I. Pak and R. Pinchasi in [1]. Our arguments work in spaces of constant curvature.

A newly synthesized dihydropyridine analogue, 2-|benzyl(phenyl)amino]ethyl l,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-l,3,2-dioxaphosphorinan-2-yl)-l-(2-morpholinoethyl)-4-(3-nitrophenyl)-3-pyridinecarboxylate (PAK-200), at 5 pM inhibited the efflux of |'H|vincristine from KB-C2 cells and increased the accumulation of |}H)vincristine in KB-C2 cells to a level similar to that in KB-3-1 cells...