Paraneoplastic pemphigus is an autoimmune blistering and erosive mucocutaneous syndrome associated with underlying neoplasm. It is primarily associated with lymphoproliferative disorders, and uncommonly with malignancies of epithelial origin. We report on a case of a 68-year-old male who presented with whole body bullous and erosive skin lesions. Findings on upper gastrointestinal endoscopy and...

CASE REPORT We review a patient with ocular manifestations of a paraneoplastic syndrome. It was a cancer-associated retinopathy (CAR) in a woman with visual loss, and attenuated and sheathed retinal arterioles. The electroretinography (ERG) showed severe abnormalities of the a and b-waves. The tumour process was not discovered until 6 months later, when a squamous neoplasia that invaded the ute...

We present the case of a female patient with a subacute paraneoplastic brainstem neurological syndrome associated with breast cancer and the development of anti-Ri antineuronal antibodies (ANNAs). It is an important syndrome to identify because of the need for urgent investigation and management to reduce progressive and irreversible neurological deterioration and to recognise the associated ri...

Background: Paraneoplastic encephalomyelitis (PEM) is a multifocal infl ammatory disorder of the central nervous system (CNS) associated with remote neoplasia. Case report: We describe a 41-year-old female patient with subacute development of dysarthria, dysphagia, tetraparesis, ataxia, breathing diffi culties and cognitive deterioration. Brain magnetic resonance imaging revealed multiple confl...

Paraneoplastic neurological syndrome (PNS) is a rare immune-mediated syndrome occurring in less than 1-3% of patients with breast cancer. Two rare cases of paraneoplastic cerebellar degeneration with breast carcinoma were reported here with a brief review of the pertinent literature. The primary indications of these two female patients were progressive lower limb weakness and gait ataxia. Both ...

Introduction. Bilateral vocal cord paralysis (BVCP) is a potential medical emergency. The Otolaryngologist plays a crucial role in the diagnosis and management of BVCP and must consider a broad differential diagnosis. We present a rare case of BVCP secondary to anti-Hu paraneoplastic syndrome. Case Presentation. A 58-year-old female presented to an Otolaryngology clinic with a history of progre...

Paraneoplastic hepatopathy has been reported with various malignancies, most commonly with renal cell cancer. This non-metastatic hepatic dysfunction in such malignancies is known as Stauffer syndrome. We describe a 61-year-old man who presented with symptoms of bowel obstruction with marked cholestasis and high levels of alkaline phosphatase and bilirubin. Imaging revealed an unremarkable live...

Paraneoplastic neurological syndromes (PNS) are remote effects of cancer that are not caused by invasion of the tumor or its metastases. Immunologic factors appear important in the pathogenesis of PNS because antineuronal autoantibodies and T-cell responses against nervous system antigens have been defined for many of these disorders. The immunologic response is elicited by the ectopic expressi...

Paraneoplastic acral vascular syndrome involves an association between malignancy and Raynaud phenomenon, gangrene, or acrocyanosis of the fingers. Raynaud phenomenon is a transient digital ischemia resulting from vasoconstriction on exposure to cold temperatures or stressful situations. In its secondary form, it is usually associated with rheumatic disease and rarely occurs as a paraneoplastic...

OBJECTIVE To describe isolated knee monoarthritis as a paraneoplastic syndrome heralding non-small cell lung cancer (NSCLC), and to discuss its clinical characteristics. METHODS Clinical records of all consecutive, new outpatients with isolated knee monoarthritis observed from January 2000 to December 2005 were reviewed. A systematic review of Medline and Cochrane Library databases was perfor...