BACKGROUND Drug hypersensitivity is classically divided into IgE mediated and non-IgE mediated disease. We report a rare case of consequent IgE mediated and non-IgE mediated reactions within the beta lactam class of antibiotics. CASE SUMMARY An 84-year-old man developed toxic epidermal necrolysis (TEN) due to ceftriaxone, a third generation cephalosporin, involving 72% of the body surface are...

INTRODUCTION We report 3 cases of dapsone hypersensitivity syndrome due to anti-malarial chemoprophylactic treatment with maloprim, in military servicemen, presenting like a viral exanthem. CLINICAL PICTURE Three male military recruits presented with fever and rash, 6 to 8 weeks after commencing on weekly doses of maloprim. TREATMENT A course of topical and systemic corticosteroids and oral...

Human herpesvirus-6 (HHV-6), a mature T-cell lymphotropic virus, is a newly recognized member of the herpes virus family and shares limited homology with human cytomegalovirus. HHV-6 has been identified as the etiologic agent of the childhood illness exanthem subitum (roseola infantum). Widespread acquisition of this virus has been demonstrated to occur early in childhood, with fever as the mos...

HHV-6 is ubiquitous in the community, appears to be acquired early in life, and has been proved to cause the clinical syndrome of exanthem subitum, and rarely to cause encephalitis. Like other herpesviruses, HHV-6 is capable of establishing latent infection and reactivating under a variety of stimuli. Improved diagnostic techniques have led to increased recognition of HHV-6 in the presence of m...

Pityriasis rosea (PR) is a common skin eruption in children that is characterized by a single skin patch that usually evolves into a widespread exanthem after one week. The duration of PR is typically six weeks and the condition is selflimited with excellent prognosis. The diagnosis is established by proper history taking and physical examination of the skin lesions. Laboratory investigations a...

H&E: hematoxylin-eosin INTRODUCTION Capnocytophaga canimorsus (Latin, canis, dog; morsus, bite) is a commensal gram-negative rod present in the oral flora of dogs; there are almost 500 reported infections, 60% of which have occurred after a dog bite, more than 80% after dog exposure, and more than 35% in the setting of alcoholism or splenectomy. Half of infections present with cutaneous manifes...