We present findings of a 10-year retrospective study, analysing the reasons for rejection neurosurgical intervention (deep brain stimulation or DBS) in patients with Parkinsons disease, who were referred to an extrapyramidal movement disorders clinic and then neurosurgery centre. It was found that after screening, 78.6% as candidates treatment rejected, while 21.4% centre, where 12% underwent s...

Background: Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) is highly effective in alleviating motor symptoms of Parkinson's disease (PD) which are not optimally controlled by dopamine replacement therapy. Clinical studies and reports suggest that STN-DBS may result in increased impulsivity and de novo impulse control disorders (ICD). Objective/Hypothesis: We aimed to compare performance o...

The expression and significance of tyrosine hydroxylase (TH) in brain tissue of rats with Parkinson's disease (PD) were explored and analyzed. A total of 120 clean-grade and healthy adult Wistar rats weighing 180-240 g were randomly divided equally into four groups according to the random number table method. Rats were sacrificed before and after the model establishment for 3, 6 or 8 weeks. The...

Artificial Neural Network (ANN)-based diagnosis of medical diseases has been taken into great consideration in recent years. In this paper, two types of ANNs are used to classify effective diagnosis of Parkinson's disease. Multi-Layer Perceptron (MLP) with back-propagation learning algorithm and Radial Basis Function (RBF) ANNs were used to differentiate between clinical variables of sampl...