The pathogenesis of aseptic loosening of total joint prostheses is not clearly understood. Two features are associated with loosened prostheses, namely, particulate debris and movement of the implant. While numerous studies have evaluated the cellular response to particulate biomaterials, few have investigated the influence of movement of the implant on the biological response to particles. Our...

Rat lung homogenates contained significant amounts of guanylate cyclase activity in both 100,000 times g (60 min) particulate and supernatant fractions. In the presence of detergent, the particulate fraction contained 40% as much activity as did the supernatant fraction. Detergent-dispersed particulate and partially purified soluble guanylate cyclase preparations were characterized with respect...

Particulate fires and explosions cause substantial loss of life and property. With the goal of understanding, preventing, or at least mitigating particulate fire and explosion hazards, we review basics. We distinguish between ‘hazard’ and ‘risk’ and discuss the fire and explosion hazards of particulates, the many factors determining such hazards, hazard indexes, and ways to reduce fire and expl...

In the present update on ocular drug delivery system, particulate carrier, the tremendous advances in ocular drug delivery system, the polymers used in particulate carriers for ocular dosage forms, the use of drug complexes and other technological advances are discussed. This review focuses on recent literature regarding mucoadhesive particulate dosage forms with special attention to in vivo st...

In an earlier report (l), we described the preparation, from sheep thyroid glands, of a particulate fraction consisting primarily of mitochondria and microsomes, which, when incubated with carrier-free radioactive iodide, converted as much as 30 per cent of the added 1131 to labeled iodoprotein. This thyroid particulate fraction differed from the cell-free thyroid preparations used by other wor...

This paper presents a non-contact sensing system for nanosized suspended particulate matter (SPM) measurements using laser-induced incandescence (LII) and laser-induced breakdown spectroscopy (LIBS). The elemental composition and density of the SPMs are determined using LIBS, and particulate size measurements are accomplished using LII. Typically, temporally resolved LII enables measurement of ...

Incorporation of metallic particulate reinforcements in eutectic Sn-Ag solder re­ sults in the formation of intermetallic compounds (IMCs) along particulate/ solder interfaces with different morphologies. For instance, “sunflower” and “blocky faceted” IMC shapes have been observed around Ni particle reinforce­ ments incorporated in the eutectic Sn-Ag solder matrix. The time and tempera­ ture ab...

PURPOSE This study was performed to evaluate the periodontal wound healing effect of particulate equine bone mineral on canine alveolar bone defects. METHODS Twelve adult male beagle dogs were used as study subjects. The mandibular second and fourth premolars were extracted prior to the experimental surgery, and the extraction sites were allowed to heal for 8 weeks. After periodontal probing,...

Respirable particulate matter generated during incomplete combustion of fossil fuels may principally target the cells found in the distal region of the lung. This study characterizes some of the effects that a model particulate matter has on the induction of heme oxygenase (HO)-1 in macrophages. HO-1 is a highly inducible stress response gene that has been demonstrated to modulate chemical, phy...

The lichen transplant monitoring methodology has been tested for source apportionment of metal deposition around the Cu smelter and former mining town of Karabash. Transplants of the lichen Hypogymnia physodes (L.) Nyl., collected from a 'control' site in July 2001, were set up at 10 stations along a 60 km NE-SW transect centred on Karabash. Samples were collected after 2 and 3 month monitoring...