Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma. The findings from transbronchial lung biopsy and bronchoalveolar lavage (BAL) were consistent with an organizing diffuse alveolar damage pattern. Once extensive microbiological studies proved negative...

INTRODUCTION Frosted branch angiitis(FBA) is a panuveitis with sheating of all retinal vesssels. CASE PRESENTATION Herein we report an immunocompetent person who presented with fever, headache, atypical rash, and hazy vision. Ophthalmoscopy of both eyes revealed perivascular sheathing with frosted branch angiitis pattern in veins, patchy retinal hemorrhages. Aqueous PCR analysis turned positi...

Intravitreal triamcinolone inhibits choroidal neovascularization. To investigate if vascular endothelial growth factor (VEGF) is affected, we examined VEGF expression after intravitreal triamcinolone administration in rat retina. Using in situ hybridization, we have found dense clustered VEGF mRNA signals in the retinal pigment epithelium, moderate patchy signals in the inner nuclear layer, and...

Alopecia areata (AA) is a common dermatological disease characterized by patchy areas of nonscarring alopecia. Sometimes, differentiating patchy AA from trichotillomania (TTM) can be difficult. We report a case of AA mimicking TTM.

We generalize the inverse patchy colloid model that was originally developed for heterogeneously charged particles with two identical polar patches and an oppositely charged equator to a model that can have a considerably richer surface pattern. Based on a Debye-Hückel framework, we propose a coarse-grained description of the effective pair interactions that is applicable to particles with an a...

Patchy particles are a popular paradigm for the design and synthesis of nanoparticles and colloids for self-assembly. In "traditional" patchy particles, anisotropic interactions arising from patterned coatings, functionalized molecules, DNA, and other enthalpic means create the possibility for directional binding of particles into higher-ordered structures. Although the anisotropic geometry of ...

Multicompartment micelles, especially those with highly symmetric surfaces such as patchy-like, patchy, and Janus micelles, have tremendous potential as building blocks of hierarchical multifunctional nanomaterials. One of the most versatile and powerful methods to obtain patchy multicompartment micelles is by the solution-state self-assembly of linear triblock copolymers. In this article, we a...

The diffraction limit is a fundamental barrier in optical microscopy, which restricts the smallest resolvable feature size of microscopic system. Microsphere-based microscopy has proven to be promosing tool for challenging limit. Nevertheless, microspheres have low imaging contrast air, hinders application this technique. In Letter, we demonstrate that challenge can effectively overcome by usin...