Abstract Crack in polymer bonded explosive (PBX) components will influence the safety and reliability of weapon system. In order to accurately simulate quasi-static fracture behavior PBX components, arc Brazilian experiment was carried out first. Then, phase field method (PFM) traditional extended finite element (XFEM) are used for comparative simulation Brazil test process, which both maximum ...

The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic cell death in a range of solid tumors. However, despite HOX proteins playing a particularly significant role in acute myeloid leukemia (AML), the relationship between HOX g...

TALE (three amino acid loop extension) homeodomain proteins include the PBC and the MEINOX sub-families. MEINOX proteins form heterodimer complexes with PBC proteins. Heterodimerization is crucial to DNA binding and for nuclear localization. PBC-MEINOX heterodimers bind DNA also in combination with HOX proteins, thereby modulating their DNA-binding specificity. TALE proteins therefore play cruc...

Vital motor functions, such as respiration and locomotion, rely on the ability of spinal motor neurons (MNs) to acquire stereotypical positions in the ventral spinal cord and to project with high precision to their peripheral targets. These key properties of MNs emerge during development through transcriptional programs that dictate their subtype identity and connectivity; however, the molecula...

Cbx1 is a dominant mutation of the bithorax complex (BX-C) of Drosophila partially transforming the second thoracic (T2) segment towards the third one (T3). Molecular analysis has shown that Cbx1 arose from a transposition within the BX-C of a DNA fragment of 17 kb containing pbx+ inserted into the Ubx area. In addition to the dominant phenotype, the Cbx1 mutation produces a set of recessive ho...

Yet for numerical simulations of detonation waves in plastic binded explosives (PBX) empirical pressure dependent reaction rates, such as ``Forest fire'' or the ``Ignition and Growth'' model, are typically used. The underlying reason for this disparity between between fundamental chemical rate laws and empirical burn models is due to the fact that a PBX is a heterogeneous material consisting of...

Homeoproteins of the Engrailed family are involved in the patterning of mesencephalic boundaries through a mechanism classically ascribed to their transcriptional functions. In light of recent reports on the paracrine activity of homeoproteins, including Engrailed, we asked whether Engrailed intercellular transfer was also involved in brain patterning and boundary formation. Using time-controll...

It is essential to estimate the Channel and detect symbol in multiple-input and multiple-output (MIMO)-orthogonal frequency division multiplexing (OFDM) systems. Symbol detection by applying the maximum likelihood (ML) detector gives excellent performance but in systems with higher number of antennas and greater constellation size, the computational complexity of this algorithm becomes quite hi...

152 words Abstract Coexpression of the homeodomain protein Meis1 and either HoxA7 or HoxA9 is characteristic of many acute myelogenous leukemias. Although Meis1 can be overexpressed in bone marrow long-term repopulating cells, it is incapable of mediating their transformation. While overexpressing HoxA9 alone transforms murine bone marrow cells, concurrent Meis1 overexpression greatly accelerat...