Pediatric malignancies are relatively rare and account for 0.5% of all cancers. The annual incidence varies between 110 and 150 per million children, which means that the chance for a child to develop a cancer during the first 15 years of life is 1:450–600. Leukemias and tumors of the brain and spinal cord have the highest relative incidence rates, followed in frequency by neuroblastoma, lympho...

Abstract Background The present randomized clinical trial evaluated the efficacy of a topical lidocaine-prilocaine cream (EMLA) to relief pain during spinal puncture in pediatric oncology patients. Materials and Methods Sixty patients with malignancy candidate for spinal puncture were selected for this study. The patients were randomly allocated to two groups. Group A had topical EMLA cream...

Abstract BACKGROUND Treatment of pediatric CNS tumors with T-cells modified chimeric antigen receptors (CARTs) provides an innovative approach. We employ GD2-directed CART-cells (GD2.CARTs) to express a constitutively active interleukin-7 receptor (C7R) increase GD2.CART survival and function independent external cytokines, thereby augmenting activity against GD2-expressing malignancies. METHOD...

Conventional anatomic brain MRI is often limited in evaluating pediatric brain tumors, the most common solid tumors and a leading cause of death in children. Advanced brain MRI techniques have great potential to improve diagnostic performance in children with brain tumors and overcome diagnostic pitfalls resulting from diverse tumor pathologies as well as nonspecific or overlapped imaging findi...

Introduction Pancreatic tumors are a rare entity, accounting for approximately 3% of cancers in the United States. Pediatric pancreatic tumors are an even rarer entity, with an incidence of 0.46 per million (under 30 years of age). The purpose of this article is to review the existing literature to give an overview of pediatric pancreatic tumors and to delineate current treatment strategies. Ma...

INTRODUCTION We present two cases of Hereditary Hemmorhagic Telengiectasia (HHT), one pediatric and the other adult, with a view to highlight the myriad cerebral and spinal vascular manifestations of this disease. The syndrome and its various findings will be reviewed including the utility of angiography in assessing the various vascular abnormalities of the cerebral and spinal vasculature. M...

Abstract OBJECTIVE Radiation-induced meningiomas (RIM) are the most common secondary neoplasm arising from radiation therapy. RIM have not been characterized in pediatric populations on a national scale despite displaying shorter latency and higher malignancy rates institutional studies. The objective of this study was to characterize compare those adult using National Cancer Institute’s Survei...