OBJECTIVE To investigate the completeness of pedigree and of number of pedigree analysis to know the acceptable familial history in Korean women with ovarian cancer. METHODS Interview was conducted in 50 ovarian cancer patients for obtaining familial history three times over the 6 weeks. The completeness of pedigree is estimated in terms of familial history of disease (cancer), health status ...

Relationship coefficients are traditionally based on pedigree data. Today, with the development of molecular techniques, they are often completely replaced by coefficients calculated from molecular data. Examples are relationships from microsatellites for biodiversity studies but also genomic relationships from SNP as currently used in genomic prediction of breeding values. There are, however, ...

作物の系譜情報は育種を行う上で必要不可欠であり，特に交配親の選定において極めて重要である．しかし，系譜情報の分析基盤や可視化ツールは少なく，育種家は範囲が限定された系譜図を使用せざるを得ない．本研究では，育種や作物データの解析に系譜情報を広く活用するため，系譜情報グラフデータベース「Pedigree Finder」（https://pedigree.db.naro.go.jp/）を構築した．系譜情報を整備するために語彙やデータフォーマットの統一を行うとともに，品種・系統の標準化されたIDを利用することにより，関連するゲノム情報および形質情報との紐づけを可能にした．系譜情報の整備にはデータモデルとしてリソース・ディスクリプション・フレームワーク（Resource Description Framework, RDF）を採用し，共通性と永続性を高めた上で，グラフデータベースを構築した．グ...

background: essential hypertension tends to a familial mode. its pattern of inheritance is heterogeneous, but the frequencies of different mode of inheritance vary in different populations. determining of the mode of inheritance in each family is the basic information that is needed for the risk estimation in those family members. determination of pattern of inheritance in families with at leas...

Pedigree Types are an intuitive ownership type system requiring minimal programmer annotations. Reusing the vocabulary of human genealogy, Pedigree Types programmers can qualify any object reference with a pedigree – a child, sibling, parent, grandparent, etc – to indicate what relationship the object being referred to has with the referant on the standard ownership tree, following the owners-a...

OBJECTIVE Identifying genotyping errors is an important issue in genetic research, yet it has been relatively less studied in samples consisting of unrelated individuals. In this article, we consider several models of genotyping errors, which were originally proposed for pedigree data, for unrelated population samples with single nucleotide polymorphism (SNP) genotype data. The mathematical con...

SUMMARY We developed a collaborative pedigree environment called CoPE. This environment includes a Java program for drawing pedigrees and a standardized system for pedigree storage. Unlike other existing pedigree programs, this software is particularly intended for epidemiologists in the sense that it allows customized automatic drawing of large numbers of pedigrees and remote and distributed c...

A novel web-based tool PedWiz that pipelines the informatics process for pedigree data is introduced. PedWiz is designed to assist researchers in the analysis of pedigree data. It provides a convenient tool for pedigree informatics: descriptive statistics, relative pairs, genetic similarity coefficients, the variance-covariance matrix for three estimated coefficients of allele identical-by-desc...

Pedigree polytopes are extensions of the classical Symmetric Traveling Salesman Problem polytopes whose graphs (1-skeletons) contain the TSP polytope graphs as spanning subgraphs. While deciding adjacency of vertices in TSP polytopes is coNP-complete, Arthanari has given a combinatorial (polynomially decidable) characterization of adjacency in Pedigree polytopes. Based on this characterization,...

The objective of this study was to test the performance of a recently proposed methodology for the estimation of realized effective size (N(e)) based on individual increase in inbreeding (DeltaF(i)) on several real pedigrees: (a) an experimental mice population; (b) a closed pedigree of fighting bulls; (c) the Spanish Purebred (SPB, Andalusian) horse pedigree; (d) the Carthusian strain of SPB p...