pemphigus vulgaris (pv) is one of the most common and studied autoimmune disorders of skin. the knock down of desmogleins in the skin by igg antibodies will eventually leads to mucocutaneous problems in both genders. targeting the cardinal molecules involved in the pathways of immune response is the main goal of given therapy. with regard to the side effects of long term use of immunosuppressiv...

pemphigus vulgaris (pv) is an autoimmune blistering disorder of the skin or mucosa. since low vitamin d status has been linked to many immune disorders, we designed this study to compare the vitamin d status in pv patients with healthy controls.in this case-control study, vitamin d status of 32 newly diagnosed pv patients was compared with 36 healthy control subjects. all patients were selected...

The word “pemphigus” is derived from the Greek term "pemphix” meaning bubble or blister. Pemphigus is a group of autoimmune diseases (see Table 4) characterized by intra-epithelial blistering, resulting in superficial vesicles or bullae that easily rupture, resulting in ulceration of mucosal and/or cutaneous sites. Although rare, pemphigus causes significant morbidity and potential mortality fo...

Pemphigus vulgaris is an autoimmune disease, in which the role of Th17 cytokines needs to be further explored. This study was performed to assess serum levels of three interleukins (IL) required for Th17 differentiation (IL-1β, IL-6 and IL-23) and two specific Th17 cytokines (IL-17 and IL-22) in a group of patients with pemphigus vulgaris, at baseline, 3 weeks and 6 months after treatment. Corr...

In this study a robust and simple classification into different stages of pemphigus, based on a set of therapeutic benchmarks including a definition of disease activity, is proposed. This staging method was validated against ELISA titres for autoantibodies against desmoglein-1 and -3. The proposed staging method was applied a priori to five newly diagnosed pemphigus patients in the course of th...

pemphigus is a rare autoimmune blistering disease with different phenotypes. the evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. however, there is no gold standard to measure the disease activity in clinical trials. in this study we aimed to introduce the pemphigus vulgaris activity score (pvas) measurement and to assess the convergent validit...

Pemphigus vulgaris is an autoimmune bullous dermatosis presenting with flaccid blisters and erosions. The morphology of pemphigus reflects the more superficial intraepidermal level split seen histologically in contrast pemphigoid, where deep below epidermis. This a case 58-year-old male clinically arcuate tense bullae, which are characteristic pemphigoid group disorders, revealed tombstoning pa...

BACKGROUND Pemphigus is a chronic autoimmune bullous disorder characterized by autoantibodies directed against desmoglein 3 and/or 1. Demonstration of intercellular deposition of IgG on the cell surface of keratinocytes by direct immunofluorescence (DIF) of the skin is the gold standard in the diagnosis of pemphigus. Recently, DIF of plucked hair demonstrating intercellular deposition of IgG in...

Aim: The aim of this case presentation was to highlight the importance awareness two different coexisting pathologies, as well emphasise that early diagnosis and prompt management are essential manage pemphigus vulgaris. Pemphigus vulgaris is a rare, life-threatening autoimmune disease characterised by presence blisters on surface oral mucosa caused antibodies against adhesion molecules cell ke...