OBJECTIVE This study aimed to investigate the association between periodontal disease and peptic ulcers in a working population. METHODS Self-administered questionnaires were distributed to all employees of a large insurance company in Japan. The questionnaire asked about their health status and lifestyle habits. Peptic ulcer was defined as either stomach ulcer, duodenal ulcer, or both. For t...

At operations on 150 patients the duodenal bulb was examined for local features which predispose it to peptic ulceration. A surgeon now has the opportunity to study the duodenum in its natural state and normal situation in both healthy and ulcerated conditions. When gastroenterostomy or partial gastrectomy were routinely used for the cure of duodenal ulcers, the bulb was either left unopened or...

Acid peptic diseases are common gastrointestinal disorders, which include gastroesophageal reflux disease, peptic ulcers, non-ulcer dyspepsia and stressrelated gastric mucosal injury. Drugs commonly used in the management of these disorders include antacids, H2 blockers, proton pump inhibitors and mucosal protective agents. In this chapter, pharmacology of these drugs will be discussed, followe...

For more than a century, peptic ulcer disease has been a major cause of morbidity and mortality. In the early part of the 20th century, when stress and diet were judged to be important pathogenetic factors for peptic ulceration, patients with peptic ulcers were treated with hospitalization, bed rest, and the prescription of “bland” diets. By the 1950s, investigators and clinicians had focused t...

The primary study objectives were to estimate the frequencies and rates of gastrointestinal bleeding and peptic ulcerative disorder in HIV-positive patients compared with age- and sex-matched HIV-negative subjects. Data from a US insurance claims database was used for this analysis. Among 89,207 patients with HIV, 9.0% had a GI bleed, 1.0% had an upper gastrointestinal bleed, 5.6% had a lower g...